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        1-12 of 26 results for 'Peter Le souef'

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        Polymorphisms in key innate immune genes and their effects on measles vaccine responses and vaccine failure in children from Mozambique

        Despite an effective vaccine, measles remains a major health problem globally, particularly in developing countries. More than 30% of children show primary... ...

        Research

        Acute infection and long term follow-up of people with HIV

        Investigators: Peter Le Souef Project description There have been almost no studies of the first illness caused by HIV infection. We have recruited adults from Mozambique who have presented to hospital with a febrile illness and determined which ...

        Research

        Genetic variants of TLR4, including the novel variant, rs5030719, and related genes are associated with susceptibility to clinical malaria in African children

        Malaria is a deadly disease caused by Plasmodium spp. Several blood phenotypes have been associated with malarial resistance, which suggests a genetic component to immune protection. ...

        Research

        Defining Age-specific Relationships of Respiratory Syncytial Virus and Rhinovirus Species in Hospitalized Children With Acute Wheeze

        Acute wheezing is one of the most common hospital presentations for young children. Respiratory syncytial virus (RSV) and rhinovirus (RV) species A, B and the more recently described species C are implicated in the majority of these presentations. However, the relative importance and age-specificities of these viruses have not been defined. ...

        Research

        Increased nasal Streptococcus pneumoniae presence in Western environment associated with allergic conditions in Chinese immigrants

        Chinese immigrants living in Australia experience increased allergic conditions: asthma, eczema, hay fever and wheeze. Recently we reported diminished innate cytokine responses in long-term immigrants, potentially increasing their pathogenic viral load and microbial carriage. We hypothesise that a Western environment changes the nasal microbiome profile, and this altered profile may be associated with the development of allergic conditions. In this cross-sectional study, we aimed to examine the loading of viral and microbial respiratory pathogens in the upper airway. ...

        Research

        Future Child Health

        Alexander Larcombe A BScEnv (Hons) PhD Team Leader, Respiratory Environmental Health Team Leader, Respiratory Environmental Health Associate Professor Alexander Larcombe began work at the Telethon Institute in 2005 and is now a Senior Research ...

        Research

        Personal network inference unveils heterogeneous immune response patterns to viral infection in children with acute wheezing

        Human rhinovirus (RV)-induced exacerbations of asthma and wheeze are a major cause of emergency room presentations and hospital admissions among children. Previous studies have shown that immune response patterns during these exacerbations are heterogeneous and are characterized by the presence or absence of robust interferon responses. ...

        Research

        TLR3 and RIG-I gene variants: Associations with functional effects on receptor expression and responses to measles viru

        Measles virus causes severe morbidity and mortality, despite the availability of measles vaccines. Successful defence against viral pathogens requires early... ...

        Research

        Rhinoviruses A and C elicit long-lasting antibody responses with limited cross-neutralization

        Rhinoviruses (RVs) can cause severe wheezing illnesses in young children and patients with asthma. Vaccine development has been hampered by the multitude of RV types with little information about cross-neutralization. We previously showed that neutralizing antibody (nAb) responses to RV-C are detected twofold to threefold more often than those to RV-A throughout childhood. Based on those findings, we hypothesized that RV-C infections are more likely to induce either cross-neutralizing or longer-lasting antibody responses compared with RV-A infections. ...

        Research

        Multi-centre, multi-disciplinary study using a systems biology approach to investigate immunomodulation in children with acute wheeze

        Ingrid Pat Laing Holt IL PG BSc PhD PhD, DSc, FRCPath, FRCPI, FAA Head, Children's Respiratory Science Emeritus Honorary Researcher 6319 1828 Ingrid.laing@telethonkids.org.au@hotmail.cmo Patrick.Holt@telethonkids.org.au Honorary Research Fellow ...

        Research

        Mechanisms of Acute Viral Respiratory Illness in Children (MAVRIC)

        Ingrid Anthony Deborah Jonatan Thomas Laing Kicic Strickland Leffler Iosifidis IL A DH JL TI BSc PhD BSc (Hons) PhD PhD PhD BSc BMedSci(Hons) PhD Head, Children's Respiratory Science Rothwell Family Fellow; Head, Airway Epithelial Research Program ...

        Research

        Genetic Variants in the IL-4/IL-13 Pathway Influence Measles Vaccine Responses and Vaccine Failure in Children from Mozambique

        We investigated IL-4, IL-13, and IL-4Rα polymorphisms and their impact on measles IgG responses and measles vaccine failure, in two separate cohort. ...

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