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        109-120 of 785 results for 'asthma'

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        Reduced transforming growth factor β1 (TGF-β1) in the repair of airway epithelial cells of children with asthma

        Evidence into the role of TGF-β1 in airway epithelial repair in asthma is still controversial. This study tested the hypothesis that the reduced TGF-β1 levels previously observed in paediatric asthmatic airway epithelial cells directly contribute to the dysregulated repair seen in these cells. ...

        Research

        A case-crossover analysis of traffic-related air pollution and emergency department presentations for asthma in Perth

        To determine whether changes in 24-hour average background ozone (O₃), nitrogen dioxide (NO₂), carbon monoxide (CO) and particulates < 10 μm (PM₁₀) increase the ...

        Research

        Vitamin D deficiency at 16 to 20 weeks' gestation is associated with impaired lung function and asthma at 6 years of age

        This paper examines whether a Vitamin D deficiency during pregnancy affects the child's lung function predisposition towards lung disease such as asthma. ...

        Research

        ACE2 expression is elevated in airway epithelial cells from older and male healthy individuals but reduced in asthma

        COVID-19 is complicated by acute lung injury, and death in some individuals. It is caused by SARS-CoV-2 that requires the ACE2 receptor and serine proteases to enter AEC. We determined what factors are associated with ACE2 expression particularly in patients with asthma and COPD. We obtained lower AEC from 145 people from two independent cohorts, aged 2-89 years, Newcastle (n = 115) and Perth (n = 30), Australia. The Newcastle cohort was enriched with people with asthma (n = 37) and COPD (n = 38). Gene expression for ACE2 and other genes potentially associated with SARS-CoV-2 cell entry was assessed by qPCR, and protein expression was confirmed with immunohistochemistry on endobronchial biopsies and cultured AEC. ...

        Research

        Developmental regulation of type 1 and type 3 interferon production and risk for infant infections and asthma development

        Type 1 and 3 interferon response capacity appears strongly developmentally constrained at birth ...

        Research

        Examining relationships between vitamin D over the first decade of life and development of asthma and allergy

        Pat Prue Holt Hart PG PH PhD, DSc, FRCPath, FRCPI, FAA BSc (Hons) MSc PhD Emeritus Honorary Researcher Head, Inflammation Patrick.Holt@telethonkids.org.au prue.hart@telethonkids.org.au Emeritus Honorary Researcher Head, Inflammation Prof Holt ...

        Research

        Developmental-associated dysregulation of innate anti-microbial immunity in early life as a determinant of susceptibility to atopic asthma

        Pat Holt PG PhD, DSc, FRCPath, FRCPI, FAA Emeritus Honorary Researcher Patrick.Holt@telethonkids.org.au Emeritus Honorary Researcher Prof Holt established the Division of Cell Biology at the Institute's inception in 1990, with his research group's ...

        Research

        Differential gene network analysis for the identification of asthma-associated therapeutic targets in allergen-specific T-helper memory responses

        Differential network analysis of allergen-induced CD4 T cell responses can unmask covert disease-associated genes and pin point novel therapeutic targets ...

        Research

        From Beneath the Skin to the Airway Wall: Understanding the Pathological Role of Adipose Tissue in Comorbid Asthma-Obesity

        This article provides a contemporary report on the role of adipose tissue in respiratory dysfunction. Adipose tissue is distributed throughout the body, accumulating beneath the skin (subcutaneous), around organs (visceral), and importantly in the context of respiratory disease, has recently been shown to accumulate within the airway wall: "airway-associated adipose tissue." Excessive adipose tissue deposition compromises respiratory function and increases the severity of diseases such as asthma. ...

        Research

        Progressive increase of FcεRI expression across several PBMC subsets is associated with atopy and atopic asthma within school-aged children

        The expression pattern of FcεRI on DC and basophils differentiates asthmatic from non-asthmatic atopic children ...

        Research

        IFNβ inhibits the development of allergen tolerance and is conducive to the development of asthma on subsequent allergen exposure

        Data indicate a role for Interferonβ in linking viral infection and allergy ...

        Research

        Characteristics associated with clinical severity and inflammatory phenotype of naturally occurring virus-induced exacerbations of asthma in adults

        Type 2 inflammation is present in patients during virus-induced asthma exacerbations, to the same degree as non-viral exacerbations ...

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