Higher dietary fiber intakes during pregnancy may have the potential health benefits of increasing gut microbiome diversity, lowering the risk of glucose intolerance and pre-eclampsia, achieving appropriate gestational weight gain, and preventing constipation. In this observational cohort study, we have assessed the dietary fiber intakes of 804 women in late pregnancy, using a semi-quantitative food frequency questionnaire (SQ-FFQ). Overall, the median (interquartile range) dietary fiber intake was 24.1 (19.0-29.7) grams per day (g/day). Only 237/804 (29.5%) women met the recommended Adequate Intake (AI) of dietary fiber during pregnancy of 28 g/day. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2020
• December 2020

In this review we examine maternal and infant dietary sources of prebiotics with a particular focus on non-digestible oligosaccharides, which undergo SCFA. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2018
• January 2018

This study used population-based record linkage to examine the association between early life risk factors and academic achievement. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2014
• January 2014

Associations between the human gut microbiome and health outcomes continues to be of great interest, although fecal sample collection methods which impact microbiome studies are sometimes neglected. Here, we expand on previous work in sample optimization, to promote high quality microbiome data. To compare fecal sample collection methods, amplicons from the bacterial 16S rRNA gene (V4) and fungal (ITS2) region, as well as short chain fatty acid (SCFA) concentrations were determined in fecal material over three timepoints. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2021
• July 2021

IgE-mediated sensitisation to egg is common in infants. In some cases, the processes leading to egg sensitisation are established in early life, even before introduction to solid foods. The underlying mechanisms remain poorly understood.  ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2024
• January 2024

In this review, we describe both the mechanisms and the therapeutic evidence from preclinical and clinical studies exploring the role of prebiotics in allergy prevention ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2019
• August 2019

Showed for the first time that the presence of an egg-derived allergen in breast milk is associated with a reduced risk of egg allergy in children at 2.5 years of age ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2020
• June 2020

Increased maternal egg ingestion is associated with increased breastmilk ovalbumin, and markers of immune tolerance in infants ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2016
• December 2016

Elucidation of early life factors is critical to understand the development of allergic diseases, especially those manifesting in early life such as food allerg ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2010
• November 2010

The ecology of the early environment - including microbial diversity, nutrition, nature, social interactions and the totality of exposures in the wider "exposome" - have life-long implications for all aspects of health and resilience. In particular, the emergence of "microbiome science" provides new evidence for vital relationships between biodiversity and health at every level. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2021
• August 2021

This paper offers a rare opportunity to longitudinally examine mental health in a population-representative study of children aged 4-5 years to 14-15 years ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2017
• November 2017

Alexander Larcombe A BScEnv (Hons) PhD Team Leader, Respiratory Environmental Health Team Leader, Respiratory Environmental Health Associate Professor Alexander Larcombe began work at the Telethon Institute in 2005 and is now a Senior Research ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2021
• November 2021