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        Identification of epithelial phospholipase A2 receptor 1 as a potential target in asthma

        PLA2R1 is increased in the airway epithelium in asthma, and serves as a regulator of airway hyperresponsiveness, airway permeability, antigen sensitization, and airway inflammation ...

        Research

        Accumulation mode particles and LPS exposure induce TLR-4 dependent and independent inflammatory responses in the lung

        We aimed to delineate the effects of LPS and AMP on airway inflammation, and potential contribution to airway disease by measuring airway inflammatory responses ...

        Research

        Conditionally reprogrammed primary airway epithelial cells maintain morphology, lineage and disease specific functional characteristics

        Here, we show that conditionally reprogrammed airway epithelial cells (CRAECs) can be established from both healthy and diseased phenotypes. ...

        Research

        Effect of human rhinovirus infection on airway epithelium tight junction protein disassembly and transepithelial permeability

        HRV-1B infection directly alters human airway epithelial TJ expression leading to increased epithelial permeability potentially via antiviral response of IL-15 ...

        Research

        The genetic and epigenetic landscapes of the epithelium in asthma

        Genetic factors in airway epithelial cells that are functionally associated with asthma pathogenesis ...

        Research

        Dissecting the regulation of bile-induced biofilm formation in staphylococcus aureus

        Wall teichoic acid may be important for protecting S. aureus against exposure to bile ...

        Research

        Bile signalling promotes chronic respiratory infections and antibiotic tolerance

        Bile acid signalling is a leading trigger for the development of chronic phenotypes underlying the pathophysiology of chronic respiratory disease ...

        Research

        Productive infection of human embryonic stem cell-derived nkx2.1+ respiratory progenitors with human rhinovirus.

        Our experiments provide proof of principle for the use of PSC-derived respiratory epithelial cells in the study of cell-virus interactions. ...

        Research

        Early respiratory viral infections in infants with cystic fibrosis

        Early viral infections were associated with greater neutrophilic inflammation and bacterial pathogens ...

        Research

        Multi-modality monitoring of cystic fibrosis lung disease: the role of chest computed tomography

        Stratification of monitoring protocols based on the risk profile of the patient can help us in the future to better care for people with Cystic Fibrosis. ...

        Research

        Suppression of adrenomedullin contributes to vascular leakage and altered epithelial repair during asthma

        The anti-inflammatory peptide, adrenomedullin (AM), and its cognate receptor are expressed in lung tissue, but its pathophysiological significance in airway... ...

        Research

        Transcription factor p63 regulates key genes and wound repair in human airway epithelial Basal cells

        The airway epithelium in asthma displays altered repair and incomplete barrier formation. ...

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