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        Romidepsin enhances the efficacy of cytarabine in vivo, revealing HDAC inhibition as a therapeutic strategy for KMT2A-rearranged acute lymphoblastic leukemia

        In this study, we investigate the in vivo synergy between romidepsin and cytarabine ...

        Research

        Toxoplasma gondii infection is associated with mitochondrial dysfunction in-vitro

        Our results show perturbation of host mitochondrial function following T. gondii infection that likely impacts on pathogenesis of disease. ...

        Research

        Childhood Hospitalisation with Infection and Cardiovascular Disease in Early-Mid Adulthood: A Longitudinal Population-Based Study

        We investigated whether childhood infection-related hospitalisation (IRH, a marker of severity) was associated with subsequent adult CVD hospitalisation. ...

        Research

        Folate pathway gene polymorphisms and risk of childhood brain tumors: Results from an Australian case-control study

        Recent research suggests that maternal folic acid supplementation is associated with a reduced risk of childhood brain tumors (CBT); polymorphisms in folate... ...

        Research

        The impact of pandemic A(H1N1)pdm09 influenza and vaccine-associated adverse events on parental attitudes and influenza vaccine uptake in young children

        This paper reports on the shift in parental attitude to vaccination after 2010, due to an unprecedented increase in febrile reactions in children receiving... ...

        Research

        Genetic and functional evaluation of the role of CXCR1 and CXCR2 in susceptibility to visceral leishmaniasis in north-east India

        IL8RA and IL8RB, encoded by CXCR1 and CXCR2, are receptors for interleukin (IL)-8 and other CXC chemokines involved in chemotaxis and activation of... ...

        Research

        Unraveling the genetics of otitis media: From mouse to human and back again

        Otitis media (OM) is among the most common illnesses of early childhood, characterised by the presence of inflammation in the middle ear cavity... ...

        Research

        AusVaxSafety

        Christopher Peter Peter Tom Blyth Jacoby Richmond Snelling CC PJ PC T MBBS (Hons) DCH FRACP FRCPA PhD BA (Hons) MSc MBBS MRCP(UK) FRACP BMBS DTMH GDipClinEpid PhD FRACP Centre Head, Wesfarmers Centre of Vaccines and Infectious Diseases; Co-Head, ...

        Research

        PneumoWA: A case-control study of the role of viral and bacterial pathogens in causing pneumonia among Western Australian children

        Christopher Elke Jennifer Peter Tom Blyth Seppanen Kent Richmond Snelling CC ES J PC T MBBS (Hons) DCH FRACP FRCPA PhD BSc PhD RN MBBS MRCP(UK) FRACP BMBS DTMH GDipClinEpid PhD FRACP Centre Head, Wesfarmers Centre of Vaccines and Infectious Diseases ...

        Research

        Patient-Reported Outcome Measures for Acute Lower Respiratory Infection (ALRI-PRO): Developing and Establishing Content Validity

        Charlie Rebecca Christopher McLeod Pavlos Blyth CM RP CC MBBS (Hons), FRACP, PhD, DTM&H, DCH PhD, MSFS, MBBS (Hons) DCH FRACP FRCPA PhD Paediatric Infectious Diseases Clinician Researcher, Research Fellow, Raine Fellow, Deputy Head of the ...

        Research

        Mapping malaria by sharing spatial information between incidence and prevalence data sets

        As malaria incidence decreases and more countries move towards elimination, maps of malaria risk in low-prevalence areas are increasingly needed. For low-burden areas, disaggregation regression models have been developed to estimate risk at high spatial resolution from routine surveillance reports aggregated by administrative unit polygons. ...

        Research

        The epidemiology of superficial Streptococcal A (impetigo and pharyngitis) infections in Australia: A systematic review

        Streptoccocal A (Strep A, GAS) infections in Australia are responsible for significant morbidity and mortality through both invasive (iGAS) and post-streptococcal (postGAS) diseases as well as preceding superficial (sGAS) skin and throat infection. The burden of iGAS and postGAS are addressed in some jurisdictions by mandatory notification systems; in contrast, the burden of preceding sGAS has no reporting structure, and is less well defined. ...

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