Acute erythroleukemia (AEL or acute myeloid leukemia [AML]-M6) is a rare but aggressive hematologic malignancy. Previous studies showed that AEL leukemic cells often carry complex karyotypes and mutations in known AML-associated oncogenes. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2020
• August 2020

As of 1 May 2020, there had been 6808 confirmed cases of COVID-19 in Australia. Of these, 98 had died from the disease. The epidemic had been in decline since mid-March, with 308 cases confirmed nationally since 14 April. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2020
• August 2020

The COVID-19 pandemic introduced challenges to everyone in society but particularly so to every aspect of medical practice. It is bewildering how quickly the profession has had to respond to rapidly changing clinical landscape. Our well-established methods involve collecting and analyzing data to generate an evidence base which is then disseminated and implemented into routine clinical practice. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2020
• August 2020

Epidemiological studies have demonstrated that survivors of acute burn trauma are at long-term increased risk of developing a range of morbidities. The mechanisms underlying this increased risk remain unknown. This study aimed to determine whether burn injury leads to sustained immune dysfunction that may underpin long-term morbidity. Plasma and peripheral blood mononuclear cells were collected from 36 pediatric burn survivors >3 years after a non-severe burn injury (<10% total body surface area) and from age/sex-matched non-injured controls. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2020
• July 2020

With the importance of early childhood development more recognized by the international society, low-cost and cross-culturally comparable measures of early childhood development is in great demand, both in China and worldwide. In this study, we aim to test the psychometrics of the Chinese version of The Early Human Capability Index (eHCI), which is designed as a measurement for school readiness in large population. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2020
• June 2020

We conclude that updated global recommendations for therapy of nutritional rickets complement previously published position statements for Australia and New Zealand ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2020
• June 2020

Baseline signatures might contribute to identifying interventional targets to be modulated prior to vaccination in order to improve vaccination responses ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2020
• June 2020

In this translational review, the mechanisms, roles, and impact of epithelial-mesenchymal transition in chronic lung diseases are discussed ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2020
• June 2020

Blood responses in very preterm infants with LOS are characterised by altered host immune responses that appear to reflect unbalanced immuno-metabolic homeostasis ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2020
• June 2020

We propose that propensity for viral exacerbations of asthma and COPD relate to delayed expression of epithelial cell innate anti-viral immune genes ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2020
• May 2020

This project aimed to investigate how schools provide support for the psychosocial wellbeing and disease management of students with type 1 diabetes ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2020
• May 2020

18 months of age infants receiving 10-valent pneumococcal Haemophilus influenzae protein D conjugate vaccine will have higher antibody levels ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2020
• May 2020