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        1297-1308 of 1360 results for '2018'

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        Pneumococcal conjugate vaccine primes mucosal immune responses to pneumococcal polysaccharide vaccine booster in Papua New Guinean children

        Invasive pneumococcal disease remains a major cause of hospitalization and death in Papua New Guinean (PNG) children. We assessed mucosal IgA and IgG responses in PNG infants vaccinated with pneumococcal conjugate vaccine (PCV) followed by a pneumococcal polysaccharide vaccine (PPV) booster. ...

        Research

        Severity Assessment in CDKL5 Deficiency Disorder

        A severity assessment was rapidly developed with input from multiple stakeholders. Refinement through ongoing validation is required for future clinical trials. ...

        Research

        Activation of ERBB4 in Glioblastoma Can Contribute to Increased Tumorigenicity and Influence Therapeutic Response

        The functional effects of increased ERBB4 activation identify ERBB4 as a potential prognostic and therapeutic target ...

        Research

        Limited impact of neonatal or early infant schedules of 7-valent pneumococcal conjugate vaccination

        Early 7vPCV schedules have limited impact on pneumococcal vaccine type carriage in PNG ...

        Research

        Genetic Research and Aboriginal and Torres Strait Islander Australians

        Human genetic research promises to deliver a range of health benefits to the population. Here we consider how the different levels of Indigenous research... ...

        Research

        Neonatal antigen-presenting cells are functionally more quiescent in children born under traditional compared with modern environmental conditions

        One explanation for the high burden of allergic and autoimmune diseases in industrialized countries is inappropriate immune development under modern... ...

        Research

        END RHD

        Glenn Jonathan Katharine Rosemary Pearson Carapetis AM Noonan Wyber G JR KN R BA (Education) PhD Candidate AM MBBS FRACP FAFPHM PhD FAHMS MBBS (Hons) MSc MBChB MPH FRACGP PhD Director of First Nations Strategy and Leadership Executive Director; ...

        Research

        The rare and undiagnosed diseases diagnostic service – application of massively parallel sequencing in a state-wide clinical service

        The Rare and Undiagnosed Diseases Diagnostic Service refers to a genomic diagnostic platform operating within the Genetic Services of Western Australia ...

        Research

        The bone marrow microenvironment of pre-B acute lymphoblastic leukemia at single-cell resolution

        The bone marrow microenvironment (BMM) plays a key role in leukemia progression, but its molecular complexity in pre-B cell acute lymphoblastic leukemia (B-ALL), the most common cancer in children, remains poorly understood. To gain further insight, we used single-cell RNA sequencing to characterize the kinetics of the murine BMM during B-ALL progression. ...

        Research

        The contribution of viruses and bacteria to community-acquired pneumonia in vaccinated children: A case - Control study

        Respiratory viruses, particularly respiratory syncytial virus and human metapneumovirus, are major contributors to pneumonia in Australian children ...

        Research

        Pre-emptive intervention versus treatment as usual for infants showing early behavioural risk signs of autism spectrum disorder

        A pre-emptive intervention for the autism spectrum disorder prodrome had no immediate treatment effect on early autism spectrum disorder symptoms ...

        Research

        Immunogenicity and safety of single-dose, 13-valent pneumococcal conjugate vaccine in pediatric and adolescent oncology patients

        All children who are receiving therapy for cancer should receive a single dose of PCV13 as soon as possible after diagnosis, regardless of prior PCV exposure. ...

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