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        Healthy Ears Clinical Trial: A telehealth-facilitated randomised-controlled trial utilising a health promotion intervention to resolve otitis media with effusion for children won specialist Ear, Nose and Throat (ENT) waiting lists

        Chris Peter Valerie Lea-Ann Ruth Jaimee Melinda Charlie Elke Tamara Robyn Brennan-Jones Richmond Swift Kirkham Thornton Rich Edmunds McLeod Seppanen Veselinovic Choi C PC VS LK RT JR ME CM ES TV RC PhD MBBS MRCP(UK) FRACP PhD PhD BNurs BSc MBBS ( ...

        Research

        Safety, tolerability, and effect of a single aural dose of Dornase alfa at the time of ventilation tube surgery for otitis media: A Phase 1b double randomized control trial

        One third of children require repeat ventilation tube insertion (VTI) for otitis media. Disease recurrence is associated with persistent middle ear bacterial biofilms. With demonstration that Dornase alfa (a DNase) disrupts middle ear effusion biofilms ex vivo, we identified potential for this as an anti-biofilm therapy to prevent repeat VTI. First, safety and tolerability needed to be measured. ...

        Research

        Ngulluk Moort, Ngulluk Boodja, Ngulluk Wirin (Our Family, Our Country, Our Spirit) Out-of-Home Care Study

        Brad Carrington Raewyn Carol Melissa Farrant Shepherd Mutch Michie O'Donnell Photos BM CCJ RM C M BSc (Hons), PhD PhD MBChB., DipRACOG., Cert.HPRT, FRACP., PhD BPsych (Hons), MPsych, GradDip Ed, PhD Co-Head, Aboriginal Health and Wellbeing Honorary ...

        Research

        Preclinical efficacy of azacitidine and venetoclax for infant KMT2A-rearranged acute lymphoblastic leukemia reveals a new therapeutic strategy

        Infants with KMT2A-rearranged B-cell acute lymphoblastic leukemia (ALL) have a dismal prognosis. Survival outcomes have remained static in recent decades despite treatment intensification and novel therapies are urgently required. ...

        Research

        Preclinical Evaluation of Carfilzomib for Infant KMT2A-Rearranged Acute Lymphoblastic Leukemia

        Infants with KMT2A-rearranged B-cell precursor acute lymphoblastic leukemia (ALL) have poor outcomes. There is an urgent need to identify novel agents to improve survival. Proteasome inhibition has emerged as a promising therapeutic strategy for several hematological malignancies. The aim of this study was to determine the preclinical efficacy of the selective proteasome inhibitor carfilzomib, for infants with KMT2A-rearranged ALL. ...

        Research

        Preclinical Evaluation of Carfilzomib for Infant KMT2A-Rearranged Acute Lymphoblastic Leukemia

        Infants with KMT2A-rearranged B-cell precursor acute lymphoblastic leukemia (ALL) have poor outcomes. There is an urgent need to identify novel agents to improve survival. Proteasome inhibition has emerged as a promising therapeutic strategy for several hematological malignancies. The aim of this study was to determine the preclinical efficacy of the selective proteasome inhibitor carfilzomib, for infants with KMT2A-rearranged ALL. ...

        Research

        Protective benefit of predominant breastfeeding against otitis media may be limited to early childhood: results from a prospective birth cohort study

        Our findings are in line with a number of epidemiological studies which show a positive association between breastfeeding and OM in early childhood ...

        Research

        Systematic chemical and molecular profiling of MLL-rearranged infant acute lymphoblastic leukemia reveals efficacy of romidepsin

        Present a valuable resource for drug discovery and have identified ROM as a promising therapeutic for MLL-rearranged iALL ...

        Research

        Raine Study - Senses Special Interest Group

        Chris Andrew Monique Sarra Brennan-Jones Whitehouse Watch and listen to Andrew Robinson Jamieson C AJ MR SE PhD PhD PhD MPsych (Clin) MAPS BSc (Hons) MSc PhD Head, Ear Health Angela Wright Bennett Professor of Autism Research at Telethon Kids ...

        Research

        Therapeutic opportunities from dissecting the pre-B leukaemia bone marrow microenvironment

        Laurence Rishi Sury Sébastien Cheung Kotecha Malinge LC RS SM BPharm (Hons) MBA PhD MB ChB (Hons) MRCPCH FRACP PhD PhD Co-Head, Leukaemia Translational Research Co-Head, Leukaemia Translational Research Laboratory Head, Translational Genomics in ...

        Research

        The Impact of Waiting Times on Behavioral Outcomes for Children with Otitis Media: Results from an Urban Ear, Nose, and Throat Telehealth Service

        Children with otitis media (OM) experience long waiting times to access Australia's public hospitals due to limited capacity. The aim of this article is to utilize an Ear, Nose, and Throat (ENT) telehealth service (the Ear Portal) to examine whether delayed access to specialist care is associated with poorer behavioral outcomes for children with OM. ...

        Research

        The bone marrow microenvironment of pre-B acute lymphoblastic leukemia at single-cell resolution

        The bone marrow microenvironment plays a key role in leukemia progression, but its molecular complexity in pre-B cell acute lymphoblastic leukemia (B-ALL), the most common cancer in children, remains poorly understood. To gain further insight, we used single-cell RNA sequencing to characterize the kinetics of the murine BMM during B-ALL progression. ...

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