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        High success rate of lung function testing in healthy, unsedated 1- and 2-year-old South African children

        Lung function measures in a health, unsedated 1- and 2-year-old children in a South African birth cohort study ...

        Research

        Novel drug targets for asthma and COPD: Lessons learned from in vitro and in vivo models

        This paper is a review of potential novel therapeutic targets or tools for the treatment of asthma and COPD. ...

        Research

        Deep or awake removal of laryngeal mask airway in children at risk of respiratory adverse events undergoing tonsillectomy - a randomised controlled trial

        We found no evidence for a difference in the timing of the laryngeal mask airways removal on the incidence of respiratory adverse events ...

        Research

        End-inspiratory molar mass step correction for analysis of infant multiple breath washout tests

        We aimed to evaluate the use of the EIMM-step method in a broad range of infants. ...

        Research

        Lung function in African infants in the Drakenstein child health study impact of lower respiratory tract illness

        Early life lower respiratory tract illness impairs lung function at 1 year, independent of baseline lung function ...

        Research

        Key paediatric messages from the 2016 european respiratory society international congress

        In this article, the Group Chairs of the Paediatric Assembly of the European Respiratory Society (ERS) highlight some of the most interesting abstracts presented at the 2016 ERS International Congress, which was held in London. ...

        Research

        Lung structural and functional impairments in young children with cystic fibrosis diagnosed following newborn screening – A nationwide observational study

        Non-invasive and sensitive clinical endpoints are needed to monitor onset and progression of early lung disease in children with cystic fibrosis (CF). We compared lung clearance index (LCI), FEV1, functional and structural lung magnetic resonance imaging (MRI) outcomes in Swiss children with CF diagnosed following newborn screening.  ...

        Research

        Multiple-breath washout as a lung function test in cystic fibrosis: A cystic fibrosis foundation workshop report

        Recent technological advances in equipment design have produced gains in popularity for this test among cystic fibrosis (CF) researchers and clinicians... ...

        Research

        Early respiratory viral infections in infants with cystic fibrosis

        Early viral infections were associated with greater neutrophilic inflammation and bacterial pathogens ...

        Research

        Using lung function measurements to greater advantage in patients with lung disease: Which test and when?

        This paper is an introduction to a series of articles about improved measurement of lung function in patients with chronic lung disease. ...

        Research

        Biomarkers to define the treatment end-point for pulmonary exacerbations in cystic fibrosis

        Graham Stephen Hall Stick GL SM BAppSci PhD CRFS FANZSRS FThorSoc FERS MB BChir PhD MRCP FRACP Honorary Research Associate Head, P4 Respiratory Health for Kids Honorary Research Associate Head, P4 Respiratory Health for Kids Professor Graham Hall is ...

        Research

        Elevated leukotriene B4 and 8-isoprostane in exhaled breath condensate from preterm-born infants

        Inflammation and oxidative stress play a key role in the development of bronchopulmonary dysplasia (BPD), possibly contributing to persistent respiratory morbidity after preterm birth. We aimed to assess if inflammatory markers were elevated in exhaled breath condensate (EBC) of infants born very prematurely (< 32 weeks gestation) at 12-16 corrected months of age, and if increased levels were associated with BPD diagnosis and respiratory morbidity. ...

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