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        1309-1320 of 1360 results for '2018'

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        Global, regional, and national life expectancy, all-cause mortality, and cause-specific mortality for 249 causes of death, 1980–2015

        Globally, life expectancy from birth increased from 61·7 years in 1980 to 71·8 years in 2015 ...

        Research

        The bone marrow microenvironment of pre-B acute lymphoblastic leukemia at single-cell resolution

        The bone marrow microenvironment plays a key role in leukemia progression, but its molecular complexity in pre-B cell acute lymphoblastic leukemia (B-ALL), the most common cancer in children, remains poorly understood. To gain further insight, we used single-cell RNA sequencing to characterize the kinetics of the murine BMM during B-ALL progression. ...

        Research

        Differences in Pneumococcal and Haemophilus influenzae Natural Antibody Development in Papua New Guinean Children in the First Year of Life

        Development of vaccines to prevent disease and death from Streptococcus pneumoniae, and nontypeable Haemophilus influenzae (NTHi), the main pathogens that cause otitis media, pneumonia, meningitis and sepsis, are a global priority. ...

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        Towards a diagnostic test for rheumatic fever

        Glenn Jonathan Michael Pat Tim Tobias Pearson Carapetis AM Serralha Holt Barnett Kollmann G JR MS PG TB TK BA (Education) PhD Candidate AM MBBS FRACP FAFPHM PhD FAHMS PhD, DSc, FRCPath, FRCPI, FAA PhD PhD, M.D., SFUW Director of First Nations ...

        Research

        Literacy and Numeracy Underachievement in Boys and Girls With ADHD

        Children with ADHD are disadvantaged from an early age in key areas of learning, and this risk increased with reduction in gestational age at birth ...

        Research

        Small-molecule screen reveals synergy of cell cycle checkpoint kinase inhibitors with DNA-damaging chemotherapies in medulloblastoma

        Medulloblastoma (MB) consists of four core molecular subgroups with distinct clinical features and prognoses. Treatment consists of surgery, followed by radiotherapy and cytotoxic chemotherapy. Despite this intensive approach, outcome remains dismal for patients with certain subtypes of MB, namely, MYC-amplified Group 3 and TP53-mutated SHH. Using high-throughput assays, six human MB cell lines were screened against a library of 3208 unique compounds. We identified 45 effective compounds from the screen and found that cell cycle checkpoint kinase (CHK1/2) inhibition synergistically enhanced the cytotoxic activity of clinically used chemotherapeutics cyclophosphamide, cisplatin, and gemcitabine. ...

        Research

        A Pre-Clinical Assessment of the Pan-ERBB Inhibitor Dacomitinib in Pediatric and Adult Brain Tumors

        Glioblastoma in adults, and medulloblastoma and pineoblastoma that mainly affect children, are aggressive brain tumors. ...

        Research

        Searching for a technology-driven acute rheumatic fever test: the START study protocol

        The absence of a diagnostic test for acute rheumatic fever (ARF) is a major impediment in managing this serious childhood condition. ARF is an autoimmune condition triggered by infection with group A Streptococcus. ...

        Research

        Targeting the mucosal immune system in a mouse model to prevent pregnancy complications following maternal bacterial infection

        Susan Pat Deborah Prescott Holt Strickland SL PG DH MBBS BMedSci PhD FRACP PhD, DSc, FRCPath, FRCPI, FAA PhD Honorary Research Fellow Emeritus Honorary Researcher Program Head, Immunobiology and Immunotherapeutic Program susan.prescott@ ...

        Research

        Influence of Toxoplasma gondii on host cell function

        Genevieve Sarra Jenefer Syn Jamieson Blackwell GS SE JM BSc (Hons), PhD BSc (Hons) MSc PhD BSc with First Class Honours, PhD, DSc, FMedSci, FAA Research Officer Senior Research Fellow Head, Genetics & Health (08) 6319 1549 Genevieve.syn@ ...

        Research

        The bone marrow microenvironment of pre-B acute lymphoblastic leukemia at single-cell resolution

        The bone marrow microenvironment (BMM) plays a key role in leukemia progression, but its molecular complexity in pre-B cell acute lymphoblastic leukemia (B-ALL), the most common cancer in children, remains poorly understood. To gain further insight, we used single-cell RNA sequencing to characterize the kinetics of the murine BMM during B-ALL progression. ...

        Research

        The contribution of viruses and bacteria to community-acquired pneumonia in vaccinated children: A case - Control study

        Respiratory viruses, particularly respiratory syncytial virus and human metapneumovirus, are major contributors to pneumonia in Australian children ...

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