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        Changing Prevalence of Lower Airway Infections in Young Children with Cystic Fibrosis

        Aspergillus species and P. aeruginosa are commonly present in the lower airways from infancy ...

        Research

        Shade coverage, ultraviolet radiation and children’s physical activity in early childhood education and care

        The provision of shade, particularly through natural forms such as tree canopy, is an important sun protection strategy and enabler of outdoor time ...

        Research

        Methodology of Young Minds Matter: The second Australian Child and Adolescent Survey of Mental Health and Wellbeing

        Aims, sample design, development of survey content, field procedures and final questionnaires of the Young Minds Matter study ...

        Research

        The effects of in utero vitamin D deficiency on airway smooth muscle mass and lung function

        In this study, we aimed to uncover the molecular mechanisms contributing to altered lung structure and function. ...

        Research

        Age at surgery and outcomes of an undescended testis

        We investigated the prevalence of UDT and examined rates of surgery and age at surgery in an Australian population. ...

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        Protocol for the systematic review of the prevention, treatment and public health management of impetigo, scabies and fungal skin infections in resource-limited settings

        The evidence derived from the review will be used to inform the development of guidelines for the management of skin infections in resource-limited settings ...

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        Improving the health of First Nations children in Australia

        Health and wellbeing of children and young people are the keys to human capability of future generations. ...

        Research

        UV exposure and protection against allergic airways disease

        Asthma is a chronic inflammatory disease of the small and large conducting airway mucosa characterised by Th2 cell immunity. ...

        Research

        Study protocol for controlled human infection for penicillin G against Streptococcus pyogenes: a double-blinded, placebo-controlled, randomised trial to determine the minimum concentration required to prevent experimental pharyngitis (the CHIPS trial)

        Regular intramuscular benzathine penicillin G injections have been the cornerstone of rheumatic heart disease (RHD) secondary prophylaxis since the 1950s. As the pharmacological correlate of protection remains unknown, it is difficult to recommend changes to this established regimen. Determining the minimum effective penicillin exposure required to prevent Streptococcus pyogenes infection will accelerate development of new long-acting penicillins for RHD prevention as well as inform opportunities to improve existing regimens. The CHIPS trial will address this knowledge gap by directly testing protection afforded by different steady state plasma concentrations of penicillin in an established model of experimental human S. pyogenes pharyngitis. ...

        Research

        Meeting the Australian 24-Hour Movement Guidelines for the Early Years is associated with better social-emotional development in preschool boys

        24-hour Movement Guidelines for the Early Years promote that achieving all three-movement behaviour (sleep, sedentary behaviour and physical activity) recommendations is important for child health and development. We examined the association between meeting all, none and combinations of the Australian 24-Hour Movement Guidelines for the Early Years and social-emotional development in 1363 preschool (2-5 years) boys (52%) and girls. ...

        Research

        Association between early respiratory viral infections and structural lung disease in infants with cystic fibrosis

        Infants with cystic fibrosis (CF) develop structural lung disease early in life, and viral infections are associated with progressive lung disease. We hypothesized that the presence of respiratory viruses would be associated with structural lung disease on computed tomography (CT) of the chest in infants with CF. ...

        Research

        The global burden of sore throat and group A Streptococcus pharyngitis: A systematic review and meta-analysis

        Contemporary data for the global burden of sore throat and group A Streptococcus (Strep A) pharyngitis are required to understand the frequency of disease and develop value propositions for Strep A vaccines. ...

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