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        Echinocandins in Pediatric Invasive Candidiasis and the Challenges of Antifungal Use in Children

        In pediatric invasive candidiasis (IC), epidemiology and risk factors differ compared to adults. Furthermore, the use of antifungals in children is challenging and requires consideration of availability and tolerability of formulations, pharmacokinetic and pharmacodynamic variations, and safety in different age groups. ...

        Research

        Early Intervention Delivery Methods for New Zealand Children with Autism: Current Practices Versus Parental Preferences

        Little is known about parent preferences regarding delivery methods of early interventions. This research examined, through parent report, the current and preferred delivery methods of seven common educational early interventions accessed by New Zealand children with autism spectrum disorder. ...

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        Brain-behavior links in autism spectrum disorder across the lifespan

        Andrew Whitehouse Watch and listen to Andrew AJ PhD Angela Wright Bennett Professor of Autism Research at Telethon Kids Institute; Director, CliniKids Andrew.Whitehouse@telethonkids.org.au Angela Wright Bennett Professor of Autism Research at ...

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        "Cannot intubate, cannot oxygenate": A novel 2-operator technique for cannula tracheotomy in an infant animal model-a feasibility study

        Evidence regarding optimal management of the "Cannot Intubate, Cannot Oxygenate" (CICO) scenario in infants is scarce. When inserting a transtracheal cannula for front of neck access direct aspiration to confirm intratracheal location is standard practice. ...

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        The relationship between meal carbohydrate quantity and the insulin to carbohydrate ratio required to maintain glycaemia is non-linear in young people with type 1 diabetes: A randomized crossover trial

        To determine if the relationship between meal carbohydrate quantity and the insulin to carbohydrate ratio (ICR) required to maintain glycaemia is linear in people with type 1 diabetes. ...

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        The Effect of Hypoglycemia on Spectral Moments in EEG Epochs of Different Durations in Type 1 Diabetes Patients

        The potential of using an electroencephalogram (EEG) to detect hypoglycemia in patients with type 1 diabetes has been investigated in both time and frequency domains. Under hyperinsulinemic hypoglycemic clamp conditions, we have shown that the brain's response to hypoglycemic episodes could be described by the centroid frequency and spectral gyration radius evaluated from spectral moments of EEG signals. ...

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        Organization and expression of the mammalian mitochondrial genome

        The mitochondrial genome encodes core subunits of the respiratory chain that drives oxidative phosphorylation and is, therefore, essential for energy conversion. Advances in high-throughput sequencing technologies and cryoelectron microscopy have shed light on the structure and organization of the mitochondrial genome and revealed unique mechanisms of mitochondrial gene regulation. ...

        Research

        The Social and Emotional Well-being of Indigenous Peoples Living With Diabetes: A Systematic Review Protocol

        Globally, Indigenous people have a greater incidence and earlier onset of diabetes than the general population and have higher documented rates of emotional distress and mental illness. This systematic review will provide a synthesis and critical appraisal of the evidence focused on the social and emotional well-being of Indigenous peoples living with diabetes, including prevalence, impact, moderators, and the efficacy of interventions. ...

        Research

        Physical activity estimated by osteogenic potential and energy expenditure has differing associations with bone mass in young adults: The Raine study

        Ground impacts during physical activity may be important for peak bone mass. We found differences in how energy expenditure and impact scores estimated from a physical activity questionnaire related to bone health in young adults. Using both estimate types can improve our understanding of the skeletal benefits of physical activity. Purpose: It is unclear whether mechanical loading during physical activity, estimated from physical activity questionnaires which assess metabolic equivalents of task (METs), is associated with skeletal health. ...

        Research

        The built environment and early childhood development: qualitative evidence from disadvantaged Australian communities

        This paper explores neighborhood-built environment features related to ‘better than expected’ and ‘as expected’ early childhood development outcomes (ECD) in 14 Australian disadvantaged communities. This paper draws from mixed methods data collected in the Kids in Communities Study–an Australian investigation of community effects on ECD–in communities across five states and territories. ...

        Research

        Variation in the prevalence of different forms of bullying victimisation among adolescents and their associations with family, peer and school connectedness: a population-based study in 40 lower and middle income to high-income countries (LMIC-HICs)

        This study aimed to estimate the prevalence of different forms of bullying victimization experiences and their association with family functioning, peer relationships and school connectedness among adolescents across 40 lower and middle income to high-income countries (LMIC-HICs). ...

        Research

        Looking beyond: complex holistic care needs of Syrian and Iraqi refugee children and adolescents

        Protracted international conflict has seen escalating numbers of displaced and resettled Syrian and Iraqi refugees, raising concerns for their health and well-being. This paper describes the demographic and clinical profiles of recently resettled Syrian and Iraqi refugee children and adolescents across physical, psychosocial, developmental and educational domains using standardised multidisciplinary assessments. ...

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