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        RSV prophylaxis use in high-risk infants in Western Australia, 2002-2013: a record linkage cohort study

        The monoclonal antibody, palivizumab is licensed for use in high-risk infants to prevent severe illness caused by respiratory syncytial virus (RSV). The level of its use and compliance with current jurisdictional guidelines which were amended in 2010, is unknown. ...

        Research

        Pneumococcal conjugate vaccine primes mucosal immune responses to pneumococcal polysaccharide vaccine booster in Papua New Guinean children

        Invasive pneumococcal disease remains a major cause of hospitalization and death in Papua New Guinean (PNG) children. We assessed mucosal IgA and IgG responses in PNG infants vaccinated with pneumococcal conjugate vaccine (PCV) followed by a pneumococcal polysaccharide vaccine (PPV) booster. ...

        Research

        Transplacental Innate Immune Training via Maternal Microbial Exposure: Role of XBP1-ERN1 Axis in Dendritic Cell Precursor Programming

        We recently reported that offspring of mice treated during pregnancy with the microbial-derived immunomodulator OM-85 manifest striking resistance to allergic airways inflammation, and localized the potential treatment target to fetal conventional dendritic cell (cDC) progenitors. Here, we profile maternal OM-85 treatment-associated transcriptomic signatures in fetal bone marrow, and identify a series of immunometabolic pathways which provide essential metabolites for accelerated myelopoiesis. ...

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        Clinical protocol for a longitudinal cohort study to identify markers of vaccine immunogenicity in newborn infants in the gambia and papua New Guinea

        Immunity is distinct in early life and greater precision is required in our understanding of mechanisms of early life protection to inform development of new pediatric vaccines ...

        Research

        Associations between clusters of early life risk factors and developmental vulnerability at age 5

        This study investigated the associations between clusters of early life risk factors and developmental vulnerability in children's first year of full-time school at age 5 ...

        Research

        Diverse Anti-Tumor Immune Potential Driven by Individual IFNα Subtypes

        Our data shows that the expression of distinct IFNα subtypes within the tumor microenvironment results in different anti-tumor activities ...

        Research

        Progress in Model Systems of Cystic Fibrosis Mucosal Inflammation to Understand Aberrant Neutrophil Activity

        Here we examine the latest findings of neutrophils in pediatric CF lung disease and proposed mechanisms of their pathogenicity ...

        Research

        A comparative study of extracellular vesicle-associated and cell-free DNA and RNA for HPV detection in oropharyngeal squamous cell carcinoma

        Our study demonstrates that although HPV-DNA/RNA can be detected in EV associated DNA/RNA, cf-DNA/RNA is the more sensitive liquid biopsy medium ...

        Research

        Development of a referral pathway framework for foetal alcohol spectrum disorder in the Pilbara

        The process of referral pathway development provided a service mapping and gapping exercise to facilitate service integration ...

        Research

        Longitudinal Analysis of Group A Streptococcus emm Types and emm Clusters in a High-Prevalence Setting: Relationship between Past and Future Infections

        No evidence of tissue tropism was observed, and there was no apparent selective pressure or constraint of emm types ...

        Research

        Introducing the ORIGINS project: a community-based interventional birth cohort

        Non-communicable diseases (NCDs) pose the greatest threat to human health globally. The dramatic rise in early onset NCDs - such as childhood obesity, the allergy epidemic and an increasing burden of mental ill health in children and youth - reflect the profound early impact of modern environments on developing systems. ...

        Research

        The misnomer of ‘high functioning autism’: Intelligence is an imprecise predictor of functional abilities at diagnosis

        We argue that 'high functioning autism' is an inaccurate clinical descriptor when based solely on intelligence quotient demarcations ...

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