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        Transcriptional blood signatures for active and amphotericin B treated visceral leishmaniasis in India

        Amphotericin B provides improved therapy for visceral leishmaniasis (VL) caused by Leishmania donovani ...

        Research

        Determining the pneumococcal conjugate vaccine coverage required for indirect protection against vaccine-type pneumococcal carriage in low and middle-income countries

        We will investigate the relationship between PCV coverage and VT carriage among undervaccinated children in Asia and the Pacific ...

        Research

        A randomized, controlled, phase 1/2 trial of a neisseria meningitidis serogroup B bivalent rLP2086 vaccine in healthy children and adolescents

        Factor H binding protein (also known as LP2086) is a conserved outer membrane neisserial lipoprotein that has emerged as a strong candidate protein antigen... ...

        Research

        An in silico pipeline to filter the Toxoplasma gondii proteome for proteins that could traffic to the host cell nucleus and influence host cell epigenetic regulation

        To identify genes with putative epigenetic functions, we developed an in silico pipeline to interrogate the T. gondii proteome of 8313 proteins ...

        Research

        Associations between natural blue and green space and preschool children's movement behaviours

        Natural outdoor environments provide important settings for children to engage in physical activity. It is unclear if these relationships also exist in preschool aged children. We examined associations between amount and type of neighbourhood vegetation and blue space, proximity to the beach and preschooler's device-measured movement behaviours. ...

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        Towards precision cancer medicine for Aboriginal and Torres Strait Islander cancer health equity

        Delivering cancer control at scale for Aboriginal and Torres Strait Islander communities is a national priority that requires Aboriginal and Torres Strait Islander leadership and codesign, as well as significant involvement of the Aboriginal community-controlled health sector. The unique genomic variation observed among Aboriginal and Torres Strait Islander peoples may have implications for standard and precision medicine. ...

        Research

        Outcomes of interventions in neonatal sepsis: A systematic review of qualitative research

        While a systematic review exists detailing neonatal sepsis outcomes from clinical trials, there remains an absence of a qualitative systematic review capturing the perspectives of key stakeholders. ...

        Research

        Estimating the impact of test–trace–isolate–quarantine systems on SARS-CoV-2 transmission in Australia

        Australian states and territories used test-trace-isolate-quarantine (TTIQ) systems extensively in their response to the COVID-19 pandemic in 2020-2021. We report on an analysis of Australian case data to estimate the impact of test-trace-isolate-quarantine systems on SARS-CoV-2 transmission.  ...

        Research

        Association of prenatal alcohol exposure with offspring DNA methylation in mammals: a systematic review of the evidence

        Prenatal alcohol exposure is associated with a range of adverse offspring neurodevelopmental outcomes. Several studies suggest that PAE modifies DNA methylation in offspring cells and tissues, providing evidence for a potential mechanistic link to Fetal Alcohol Spectrum Disorder. ...

        Research

        Foetal growth restriction in mice modifies postnatal airway responsiveness in an age and sex-dependent manner

        Our data demonstrate changes in airway responsiveness as a result of intrauterine growth restriction that could influence susceptibility to asthma development ...

        Research

        International consensus on use of continuous glucose monitoring

        This article summarizes the ATTD consensus recommendations and represents the current understanding of how CGM results can affect outcomes. ...

        Research

        Optical coherence tomography-based contact indentation for diaphragm mechanics in a mouse model of transforming growth factor alpha induced lung disease

        This study tested the utility of optical coherence tomography-based indentation to assess mechanical properties of respiratory tissues in disease ...

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