Obesity is a contributing factor to asthma severity; while it has long been understood that obesity is related to greater asthma burden, the mechanisms though which this occurs have not been fully elucidated. One common explanation is that obesity mechanically reduces lung volume through accumulation of adipose tissue external to the thoracic cavity. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2024
• April 2024

This study aimed to investigate the effects of different macro-environments on asthma genotype-phenotype associations in 2 geographically separated populations ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2010
• February 2010

Citation: Donovan GM, Wang KCW, Elliot JG, James AL, Noble PB. Quantifying airway remodelling for research or clinical purposes: How should we normalize for airway size? Respirology. 2023 Keywords: Asthma; pathology; respiratory structure and ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2023
• January 2023

Human rhinovirus (RV)-induced exacerbations of asthma and wheeze are a major cause of emergency room presentations and hospital admissions among children. Previous studies have shown that immune response patterns during these exacerbations are heterogeneous and are characterized by the presence or absence of robust interferon responses. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2021
• December 2021

Intrauterine growth restriction (IUGR) is associated with asthma. Murine models of IUGR have altered airway responsiveness in the absence of any inflammatory exposure. Given that a primary feature of asthma is airway inflammation, IUGR-affected individuals may develop more substantial respiratory impairment if subsequently exposed to an allergen. This study used a maternal hypoxia-induced mouse model of IUGR to determine the combined effects of IUGR and allergy on airway responsiveness. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2021
• May 2021

There is evidence to suggest an association between prenatal maternal stress and the development of asthma or other atopic diseases in offspring. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2014
• July 2014

We employed a systems biology approach to delineate upper airway gene network patterns underlying asthma exacerbation phenotypes in children. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2017
• November 2017

An improved understanding of the roles of protein kinases in intracellular signalling and disease progression has driven significant advances in protein... ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2011
• March 2011

Ingrid Pat Laing Holt IL PG BSc PhD PhD, DSc, FRCPath, FRCPI, FAA Head, Children's Respiratory Science Emeritus Honorary Researcher 6319 1828 Ingrid.laing@telethonkids.org.au@hotmail.cmo Patrick.Holt@telethonkids.org.au Honorary Research Fellow ...

• 1. Telethon Kids Institute
• Projects

Malaria is a deadly disease caused by Plasmodium spp. Several blood phenotypes have been associated with malarial resistance, which suggests a genetic component to immune protection. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2023
• Jun 2023

Eczema often precedes the development of asthma in a disease course called the 'atopic march'. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2015
• January 2015

Rhinoviruses (RVs) can cause severe wheezing illnesses in young children and patients with asthma. Vaccine development has been hampered by the multitude of RV types with little information about cross-neutralization. We previously showed that neutralizing antibody (nAb) responses to RV-C are detected twofold to threefold more often than those to RV-A throughout childhood. Based on those findings, we hypothesized that RV-C infections are more likely to induce either cross-neutralizing or longer-lasting antibody responses compared with RV-A infections. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2023
• August 2023