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        133-144 of 170 results for 'fiona stanley'

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        Bacillus Calmette-Guérin vaccination for protection against recurrent herpes labialis: a nested randomised controlled trial

        Recurrences of herpes simplex virus (HSV) in the orofacial region (herpes labialis or cold sores) impact quality-of-life. We aimed to study whether the bacille Calmette-Guérin (BCG) vaccine can attenuate cold sore recurrences through off-target immunomodulatory effects. ...

        Research

        Bacille Calmette-Guérin vaccination to prevent febrile and respiratory illness in adults (BRACE): secondary outcomes of a randomised controlled phase 3 trial

        Bacille Calmette-Guérin (BCG) vaccination has off-target (non-specific) effects that are associated with protection against unrelated infections and decreased all-cause mortality in infants. We aimed to determine whether BCG vaccination prevents febrile and respiratory infections in adults. ...

        Research

        Factors influencing scar formation following Bacille Calmette-Guérin (BCG) vaccination

        The prevalence of scar formation following Bacille Calmette-Guérin (BCG) vaccination varies globally. The beneficial off-target effects of BCG are proposed to be stronger amongst children who develop a BCG scar. Within an international randomised trial ('BCG vaccination to reduce the impact of coronavirus disease 2019 (COVID-19) in healthcare workers'; BRACE Trial), this nested prospective cohort study assessed the prevalence of and factors influencing scar formation, as well as participant perception of BCG scarring 12 months following vaccination. ...

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        The association between otitis media in early childhood with later behaviour and attention problems: A longitudinal pregnancy cohort

        The present study aims to investigate the association between an early history of recurrent otitis media (OM) with or without ventilation tube insertion and later behavioural problems in childhood and adolescence. ...

        Research

        Long-term follow-up after recurrent otitis media and ventilation tube insertion: Hearing outcomes and middle-ear health at six years of age

        To investigate the long-term impact of recurrent otitis media (rOM) and ventilation tube insertion (VTI) in early childhood on hearing outcomes and middle-ear health three to five years later, in a prospective pregnancy cohort study. ...

        Research

        Unlocking the immunology of whooping cough vaccines to guide the development of improved vaccines and schedules in Australia

        Ruth Peter Thornton Richmond RT PC PhD MBBS MRCP(UK) FRACP Co-head, Bacterial Respiratory Infectious Disease Group (BRIDG) Head, Vaccine Trials Group Co-head, Bacterial Respiratory Infectious Disease Group (BRIDG) Head, Vaccine Trials Group Dr Ruth ...

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        Qualitative assessment of healthy volunteer experience receiving subcutaneous infusions of high-dose benzathine penicillin G (SCIP) provides insights into design of late phase clinical studies

        Secondary prophylaxis to prevent rheumatic heart disease (RHD) progression, in the form of four-weekly intramuscular benzathine benzylpenicillin G (BPG) injections, has remained unchanged since 1955. Qualitative investigations into patient preference have highlighted the need for long-acting penicillins to be delivered less frequently, ideally with reduced pain. ...

        Research

        Recurrent otitis media and behaviour problems in middle childhood: A longitudinal cohort study

        To investigate the long-term effects of early-life recurrent otitis media (OM) and subsequent behavioural problems in children at the age of 10 years. ...

        Research

        "Hurts less, lasts longer"; a qualitative study on experiences of young people receiving high-dose subcutaneous injections of benzathine penicillin G to prevent rheumatic heart disease in New Zealand

        Four-weekly intramuscular benzathine penicillin G injections to prevent acute rheumatic fever progression have remained unchanged since 1955. A Phase-I trial in healthy volunteers demonstrated the safety and tolerability of high-dose subcutaneous infusions of BPG which resulted in a much longer effective penicillin exposure, and fewer injections. Here we describe the experiences of young people living with ARF participating in a Phase-II trial of SubCutaneous Injections of BPG. ...

        Research

        Goroka Otitis Media Study: Prevalence and associated risk factors of otitis media in children attending urban clinics in Goroka, Eastern Highlands Province of Papua New Guinea

        Deborah Chris Tamara Lehmann Brennan-Jones Veselinovic D C TV AO, MBBS, MSc PhD MClinAud Honorary Emeritus Fellow Head, Ear Health Clinical Research Officer/PhD student chris.brennan-jones@telethonkids.org.au tamara.veselinovic@telethonkids.org.au ...

        Research

        High prevalence of hearing loss in urban Aboriginal infants: the Djaalinj Waakinj cohort study

        Chris Deborah Tamara Brennan-Jones Lehmann Veselinovic C D TV PhD AO, MBBS, MSc MClinAud Head, Ear Health Honorary Emeritus Fellow Clinical Research Officer/PhD student chris.brennan-jones@telethonkids.org.au tamara.veselinovic@telethonkids.org.au ...

        Research

        Development of a sustained release implant of benzathine penicillin G for secondary prophylaxis of rheumatic heart disease

        Regular intramuscular (i.m.) benzathine penicillin G (BPG) injections have been the cornerstone of rheumatic heart disease (RHD) secondary prophylaxis since the 1950s. Patient adherence to IM BPG is poor, largely due to pain, the need for regular injections every 3-4 weeks and health sector delivery challenges in resource-limited settings. There is an urgent need for new approaches for secondary prophylaxis, such as an implant which could provide sustained penicillin concentrations for more than 6 months. ...

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