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        The prevalence of and potential risk factors for Developmental Language Disorder at 10 years in the Raine Study

        This study sought to determine the prevalence of Developmental Language Disorder (DLD) in Australian school-aged children and associated potential risk factors for DLD at 10 years. ...

        Research

        Modeling COVID-19 disease processes by remote elicitation of causal Bayesian networks from medical experts

        COVID-19 is a new multi-organ disease causing considerable worldwide morbidity and mortality. While many recognized pathophysiological mechanisms are involved, their exact causal relationships remain opaque. Better understanding is needed for predicting their progression, targeting therapeutic approaches, and improving patient outcomes. While many mathematical causal models describe COVID-19 epidemiology, none have described its pathophysiology. ...

        Research

        Pre-natal, clonal origin of t(1;11)(p32;q23) acute lymphoblastic leukemia in monozygotic twins

        Investigation of this rare mixed lineage leukemia cytogenetic abnormality aims to provide further evidence of the genetic changes that underpin this leukemia. ...

        Research

        Histiologic chorioamnionitis is associated with reduced incidence of late-onset sepsis in very preterm infants

        Histologic chorioamnionitis (HCA) is implicated in the onset of preterm labor and delivery. Chorioamnionitis is a known risk factor for early-onset sepsis... ...

        Research

        Immunogenicity and safety of a combined Haemophilus influenzae type b-Neisseria

        Neisseria meningitidis serogroups B, C, and Y cause most meningococcal disease in industrialized countries... ...

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        The impact of respiratory viruses on lung health after preterm birth

        The aim of this review is to highlight the risk factors that may contribute to increased susceptibility to viral respiratory infections among preterm infants ...

        Research

        Development of new preclinical models of childhood leukaemia

        Sébastien Laurence Rishi Sury Malinge Cheung Kotecha SM LC RS PhD BPharm (Hons) MBA PhD MB ChB (Hons) MRCPCH FRACP PhD Laboratory Head, Translational Genomics in Leukaemia, Ursula Kees Fellow (CCRF), Cancer Council WA Fellow (CCWA), Senior Research ...

        Research

        Prostaglandin E2 imprints a long-lasting effect on dendritic cell progenitors in the bone marrow

        Injection of BM-differentiated DCs from nonchimeric mice restored the reduced immune responses of PGE2-chimeric mice. ...

        Research

        Acute Erythemal Ultraviolet Radiation Causes Systemic Immunosuppression in the Absence

        Vitamin D is synthesised by ultraviolet (UV) irradiation of skin and is hypothesized to be a direct mediator. ...

        Research

        Targeting cytokine- and therapy-induced PIM1 activation in preclinical models of T-cell acute lymphoblastic leukemia and lymphoma

        IL7 and glucocorticoids coordinately drive aberrant activation of PIM1 and suggests that T-ALL and T-LBL patients could benefit from PIM inhibition ...

        Research

        Effectiveness of clindamycin and intravenous immunoglobulin, and risk of disease in contacts, in invasive group a streptococcal infections

        This paper reports on treatment, and preventing infection in close contact, of invasive group A streptococcal (iGAS) using the antibiotic clindamycin and... ...

        Research

        Vitamin D over the first decade and susceptibility to childhood allergy and asthma

        We aimed to research relationships between 25(OH)D levels from birth to 10 y/o and susceptibility to allergic sensitization, respiratory issues and asthma. ...

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