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        1465-1476 of 1501 results for 'clinical trials'

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        The effects of in utero vitamin D deficiency on airway smooth muscle mass and lung function

        In this study, we aimed to uncover the molecular mechanisms contributing to altered lung structure and function. ...

        Research

        ORIGINS of Neurodevelopmental Risk and Resilience

        Amy Jenny Andrew Helen Deborah Martyn Melissa Phil Kandice Gail Vincent Finlay-Jones Downs Whitehouse Watch and listen to Andrew Leonard Strickland Symons Licari Stumbles Varcin Alvares Mancini AFJ JA AJ HM DH MS ML PS KJ GA VOM BPsych(Hons), MPsych ...

        Research

        A randomised controlled trial of an iPad-based application to complement early behavioural intervention in Autism Spectrum Disorder

        Technology-based interventions may provide a relatively low-cost addition to existing therapist-delivered interventions for children with ASD ...

        Research

        Sex-Specific Environmental Impacts on Initiation and Progression of Multiple Sclerosis

        The immunological mechanisms that contribute to multiple sclerosis (MS) differ between males and females. Females are 2-3 times more likely to develop MS compared to males, however the reason for this discrepancy is unknown. Once MS is established, there is a more inflammatory yet milder form of disease in females whereas males generally suffer from more severe disease and faster progression, neural degradation, and disability. ...

        Research

        Mothers' and Fathers' Work Hours, Child Gender, and Behavior in Middle Childhood

        This study examined the association between typical parental work hours (including nonemployed parents) and children's behavior in two-parent heterosexual... ...

        Research

        Bullying and psychosocial adjustment among children with and without asthma

        Children with asthma face serious mental health risk, but the pathways remain unclear. This study aimed to examine bullying victimisation and perpetration in children with asthma and a comparison sample without a chronic health condition, and the role of bullying in moderating psychosocial adjustment outcomes for those with asthma. A sample of children with and without asthma, and their parents, were recruited from hospital clinics. ...

        Research

        Metabolic dysfunction induced by a high-fat diet modulates hematopoietic stem and myeloid progenitor cells in brown adipose tissue of mice

        Brown adipose tissue (BAT) may be an important metabolic regulator of whole-body glucose. While important roles have been ascribed to macrophages in regulating metabolic functions in BAT, little is known of the roles of other immune cells subsets, particularly dendritic cells (DCs). Eating a high-fat diet may compromise the development of hematopoietic stem and progenitor cells (HSPCs)-which give rise to DCs-in bone marrow, with less known of its effects in BAT. We have previously demonstrated that ongoing exposure to low-dose ultraviolet radiation (UVR) significantly reduced the 'whitening' effect of eating a high-fat diet upon interscapular (i) BAT of mice. ...

        Research

        Sub-erythemal ultraviolet radiation reduces metabolic dysfunction in already overweight mice

        Exposure to sunlight may limit cardiometabolic risk. ...

        Research

        Dietary Vitamin D Increases Percentages and Function of Regulatory T Cells in the Skin-Draining Lymph Nodes and Suppresses Dermal Inflammation

        Dietary vitamin D3 increased the suppressive activity of regulatory T cells in the skin-draining lymph nodes, which are poised to suppress dermal inflammation ...

        Research

        The PneuCarriage Project: A Multi-Centre Comparative Study to Identify the Best Serotyping Methods for Examining Pneumococcal Carriage

        The PneuCarriage project, a large, international multi-centre study for the identification of the best pneumococcal serotyping methods for carriage studies ...

        Research

        Study protocol of a multicentre, randomised, controlled trial evaluating the effectiveness of probiotic and peanut oral immunotherapy in inducing desensitisation or tolerance in children with peanut allergy compared with oral immunotherapy

        Peanut allergy is the the most common cause of life-threatening food-induced anaphylaxis. There is currently no effective long-term treatment. There is a pressing need for definitive treatments that improve the quality of life and prevent fatalities. ...

        Research

        LPS binding protein and activation signatures are upregulated during asthma exacerbations in children

        Asthma exacerbations in children are associated with respiratory viral infection and atopy, resulting in systemic immune activation and infiltration of immune cells into the airways. The gene networks driving the immune activation and subsequent migration of immune cells into the airways remains incompletely understood. Cellular and molecular profiling of PBMC was employed on paired samples obtained from atopic asthmatic children during acute virus-associated exacerbations and later during convalescence. ...

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