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        Prenatal Exposure to General Anesthesia and Childhood Behavioral Deficit

        Exposure to surgery and anesthesia in early childhood has been found to be associated with an increased risk of behavioral deficits. While the US Food and Drug Administration (FDA) has warned against prenatal exposure to anesthetic drugs, little clinical evidence exists to support this recommendation. ...

        Research

        Pediatric pineoblastoma: A pooled outcome study of North American and Australian therapeutic data

        Pineoblastoma is a rare brain tumor usually diagnosed in children. Given its rarity, no pineoblastoma-specific trials have been conducted. Studies have included pineoblastoma accruing for other embryonal tumors over the past 30 years. ...

        Research

        Qualitative assessment of healthy volunteer experience receiving subcutaneous infusions of high-dose benzathine penicillin G (SCIP) provides insights into design of late phase clinical studies

        Secondary prophylaxis to prevent rheumatic heart disease (RHD) progression, in the form of four-weekly intramuscular benzathine benzylpenicillin G (BPG) injections, has remained unchanged since 1955. Qualitative investigations into patient preference have highlighted the need for long-acting penicillins to be delivered less frequently, ideally with reduced pain. ...

        Research

        Vitamin D 3 deficiency enhances allergen-induced lymphocyte responses in a mouse model of allergic airway disease

        In this study, using a mouse model, we determined whether vitamin D deficiency in utero and during early life modulated the severity of asthma. ...

        Research

        The current state of play of rodent models to study the role of vitamin D in UV-induced immunomodulation

        Ultraviolet radiation (UVR) from sunlight is immunomodulatory and the main source of vitamin D for humans. ...

        Research

        UV exposure and protection against allergic airways disease

        Asthma is a chronic inflammatory disease of the small and large conducting airway mucosa characterised by Th2 cell immunity. ...

        Research

        A systematic review of the evidence that swimming pools improve health and wellbeing in remote Aboriginal communities in Australia

        The benefits that swimming pools may bring to to ear and eye health in remote Aboriginal communities remains unresolved ...

        Research

        The effects of in utero vitamin D deficiency on airway smooth muscle mass and lung function

        In this study, we aimed to uncover the molecular mechanisms contributing to altered lung structure and function. ...

        Research

        Djaalinj Waakinj: A cohort study of otitis media in young urban Aboriginal children – prevalence, risk factors and consequences

        Chris Deborah Peter Natasha Valerie Brennan-Jones Lehmann Richmond Morrison Swift C D PC NM VS PhD AO, MBBS, MSc MBBS MRCP(UK) FRACP Head, Ear Health Honorary Emeritus Fellow Head, Vaccine Trials Group Aboriginal Researcher Aboriginal Co-Director, ...

        Research

        Personalised analytics for rare disease diagnostics

        Here we focus on the problem of prioritising variants with respect to the observed disease phenotype ...

        Research

        Genetic and functional evidence for a role for SLC11A1 in susceptibility to otitis media in early childhood in a Western Australian population

        Otitis media (OM) is a common disease in early childhood characterised by inflammation of the middle ear. ...

        Research

        Genome-Wide Association Study to Identify the Genetic Determinants of Otitis Media Susceptibility in Childhood

        We identified several novel candidate genes which warrant further analysis in cohorts matched more precisely for clinical phenotypes. ...

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