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        1501-1512 of 1772 results for 'early life'

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        Mechanisms of Acute Viral Respiratory Illness in Children (MAVRIC)

        Ingrid Anthony Deborah Jonatan Thomas Laing Kicic Strickland Leffler Iosifidis IL A DH JL TI BSc PhD BSc (Hons) PhD PhD PhD BSc BMedSci(Hons) PhD Head, Children's Respiratory Science Rothwell Family Fellow; Head, Airway Epithelial Research Program ...

        Research

        An infant mouse model of influenza-driven nontypeable Haemophilus influenzae colonization and acute otitis media suitable for preclinical testing of novel therapies

        Nontypeable Haemophilus influenzae (NTHi) is a major otitis media (OM) pathogen, with colonization a prerequisite for disease development. Most acute OM is in children <5 years old, with recurrent and chronic OM impacting hearing and learning. Therapies to prevent NTHi colonization and/or disease are needed, especially for young children. Respiratory viruses are implicated in driving the development of bacterial OM in children. ...

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        Characterization of regulatory dendritic cells differentiated from the bone marrow of UV-irradiated mice

        In summary, UV-BMDCs do not express the classical phenotypic or gene expression properties of DCs reported by others as 'regulatory' or 'tolerogenic'. ...

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        Vitamin D status and predictors of serum 25-hydroxyvitamin D concentrations in Western Australian adolescents

        Using prospective data from the Western Australian Pregnancy Cohort (Raine) Study, we investigated vitamin D status and predictors of serum 25-hydroxyvitamin... ...

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        ASCOT ADAPT study of COVID-19 therapeutics in hospitalised patients: an international multicentre adaptive platform trial

        SARS-CoV-2 infection is associated with a significant risk of hospitalisation, death, and prolonged impact on quality of life. Evaluation of new treatment options and optimising therapeutic management of people hospitalised with SARS-CoV-2 infection remains essential, but rapid changes in pandemic conditions and potential therapies have limited the utility of traditional approaches to randomised controlled trials. ...

        Research

        In vitro antibacterial activity of Western Australian honeys, and manuka honey, against bacteria implicated in impetigo

        Impetigo is a contagious skin disease caused by Staphylococcus aureus and Streptococcus pyogenes. Without treatment, impetigo may be recurrent, develop into severe disease, or have serious, life-threatening sequelae. Standard treatment consists of topical or systemic antibiotic therapy (depending on severity), however, due to antibiotic resistance some therapies are increasingly ineffective. ...

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        Chemotherapy increases amenability of surgical resection in congenital glioblastoma

        Brain tumors presenting in infancy, especially during the first 6 months of life. ...

        Research

        “Coronavirus Changed the Rules on Everything”: Parent Perspectives on How the COVID‐19 Pandemic Influenced Family Routines, Relationships and Technology Use in Families with Infants

        This study explores how the first wave of the COVID‐19 pandemic influenced family routines, relationships and technology use (smartphones and tablet computers) among families with infants. Infancy is known to be an important period for attachment security and future child development, and a time of being susceptible to changes within and outside of the family unit. ...

        Research

        Bullying and psychosocial adjustment among children with and without asthma

        Children with asthma face serious mental health risk, but the pathways remain unclear. This study aimed to examine bullying victimisation and perpetration in children with asthma and a comparison sample without a chronic health condition, and the role of bullying in moderating psychosocial adjustment outcomes for those with asthma. A sample of children with and without asthma, and their parents, were recruited from hospital clinics. ...

        Research

        Patterns of sedentary time and ambulatory physical activity in a Danish population of girls and women with Rett syndrome

        We aimed to: (1) describe the patterns of sedentary time and daily steps and (2) identify the association of individual and environmental characteristitics. ...

        Research

        The Sun Safe app: a new online tool to promote safe sun behaviours by teenagers

        Gail Prue Shelley Alvares Hart Gorman GA PH S PhD BSc (Hons) MSc PhD BSc (Hons) PhD Senior Research Fellow Head, Inflammation Honorary Research Associate 08 6319 1698 gail.alvares@telethonkids.org.au prue.hart@telethonkids.org.au shelley.gorman@ ...

        Research

        Developing an Online Tool to Promote Safe Sun Behaviors With Young Teenagers as Co-researchers

        Despite education about the risks of excessive sun exposure, teenagers in Australia are sun-seeking, with sunburn common in summer. Conversely, some regular (time-limited) exposure to sunlight (that avoids sunburn) is necessary for vitamin D and healthy bones and other molecules important for immune and metabolic health. New interventions are thus required to better support teenagers to make healthy and balanced decisions about their sun behaviors. ...

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