Our results show that TRM cells have a fundamental role in the surveillance of subclinical melanomas in the skin by maintaining cancer-immune equilibrium ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2019
• January 2019

Acute megakaryoblastic leukemia of Down syndrome (DS-AMKL) is a model of clonal evolution from a preleukemic transient myeloproliferative disorder requiring both a trisomy 21 (T21) and a GATA1s mutation to a leukemia driven by additional driver mutations. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2022
• July 2022

Research focused on Down syndrome has increased in the last several years to advance understanding of the consequences of trisomy 21 (T21) on molecular and cellular processes and, ultimately, on individuals with Down syndrome. The Trisomy 21 Research Society (T21RS) is the premier scientific organization for researchers and clinicians studying Down syndrome. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2021
• July 2021

Haematological malignancies, although a broad range of specific disease types, continue to show considerable overlap in classification, and patients are... ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2015
• May 2015

DNA methylation array profiling for classifying pediatric central nervous system (CNS) tumors is a valuable adjunct to histopathology. However, unbiased prospective and interlaboratory validation studies have been lacking. The AIM BRAIN diagnostic trial involving 11 pediatric cancer centers in Australia and New Zealand. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2023
• October 2023

The seven key challenges summarized in this Position Paper are intended to serve as foci for future research and investment in brain tumours ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2019
• August 2019

Laurence Rishi Sury Sébastien Cheung Kotecha Malinge LC RS SM BPharm (Hons) MBA PhD MB ChB (Hons) MRCPCH FRACP PhD PhD Co-Head, Leukaemia Translational Research Co-Head, Leukaemia Translational Research Laboratory Head, Translational Genomics in ...

• Telethon Kids Institute
• Projects

Our findings present a novel mouse model for glioma demonstrating that the PI3K pathway is important for initiation of tumorigenesis ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2018
• September 2018

Whole genome sequencing of poor and exceptional survivors identified a gain in Chromosome 19 that was exclusive to the exceptional survivors ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2019
• December 2019

To estimate the levels of exposure to diesel exhaust expressed by EC in the mining industry and to describe the risk of lung cancer that may result from it. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2017
• November 2017

Despite low ERBB4 mRNA in glioblastoma, the functional effects of increased ERBB4 activation identify ERBB4 as a potential prognostic and therapeutic target ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2018
• July 2018

Nick Gottardo NG MBChB FRACP PhD Co-Head, Brain Tumour Research nicholas.gottardo@telethonkids.org.au Co-Head, Brain Tumour Research Professor Nick Gottardo co-leads the Brain Tumour Research Programme at the Telethon Kids Institute. He is also Head ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2021
• June 2021