Mucopolysaccharidosis type IIIA (MPS IIIA) is characterized by neurological and skeletal pathologies caused by reduced activity of the lysosomal hydrolase, sulfamidase, and the subsequent primary accumulation of undegraded heparan sulfate (HS). Respiratory pathology is considered secondary in MPS IIIA and the mechanisms are not well understood.  ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2024
• June 2024

Diesel engine exhaust exposures were higher in underground miners and had a negative association with their lung function over a single 12-h shift ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2020
• May 2020

Persistent respiratory bacterial infections are a clinical burden in several chronic inflammatory airway diseases and are often associated with neutrophil infiltration into the lungs. Following recruitment, dysregulated neutrophil effector functions such as increased granule release and formation of neutrophil extracellular traps (NETs) result in damage to airway tissue, contributing to the progression of lung disease. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2022
• December 2022

Wall teichoic acid may be important for protecting S. aureus against exposure to bile ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2016
• August 2016

Our data associates IL-1α with early structural lung damage in CF and suggests this pathway as a novel anti-inflammatory target ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2018
• November 2018

Few studies exist investigating lung function trajectories of those born preterm; however growing evidence suggests some individuals experience increasing airway obstruction throughout life. Here we use the studies identified in a recent systematic review to provide the first meta-analysis investigating the impact of preterm birth on airway obstruction measured by the forced expiratory volume in 1 s (FEV1) to forced vital capacity (FVC) ratio. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2023
• Jun 2023

Exhaled breath temperature (EBT) has been proposed for the non-invasive assessment of airway inflammation ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2011
• May 2011

Exposure to diesel exhaust particles (DEP) is thought to exacerbate many pre-existing respiratory diseases. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2012
• September 2012

Stephen Yuliya Stick Karpievitch SM YK MB BChir PhD MRCP FRACP PhD, MS, BS Head, P4 Respiratory Health for Kids Ai and Data Analytics Lead, Respiratory Research +61863191356 yuliya.karpievitch@telethonkids.org.au Head, P4 Respiratory Health for Kids ...

• 1. Telethon Kids Institute
• Our research
• Chronic and Severe Diseases
• Respiratory Health Program
• P4 Respiratory Health for Kids

Understanding early triggers of Cystic Fibrosis Lung Disease ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2016
• October 2016

Infant lung function (ILF) testing may provide useful information about lung growth and susceptibility to respiratory disease. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2013
• December 2013

Protease elastase exocytosis by airway neutrophils occurs in all cystic fibrosis children, and its cellular measure correlates with early lung damage ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2019
• April 2019