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        Respiratory tract exacerbations revisited: Ventilation, inflammation, perfusion, and structure (VIPS) monitoring to redefine treatment

        For cystic fibrosis (CF) patients older than 6 years there are convincing data that suggest respiratory tract exacerbations (RTE) play an important role in... ...

        Research

        Phenotypic, functional, and plasticity features of classical and alternatively activated human macrophages

        Human peripheral blood monocytes were differentiated into uncommitted macrophages (M0) and then polarized to M1 and M2 phenotypes using LPS/IFN-gamma... ...

        Research

        Transcriptional dynamics reveal critical roles for non-coding RNAs in the immediate-early response

        The immediate-early response mediates cell fate in response to a variety of extracellular stimuli and is dysregulated in many cancers. ...

        Research

        Relationship between cytokine expression patterns and clinical outcomes: two population-based birth cohorts

        Our findings suggest that positive HDM 'allergy tests' and asthma are associated with a broad range of immunophenotypes, which may have important... ...

        Research

        Rheumatic heart disease: Tools for implementing programmes

        This article discusses the World Health Organization program for monitoring & managing rheumatic heart disease. ...

        Research

        Reversibility of trapped air on chest computed tomography in cystic fibrosis patients

        To investigate changes in trapped air volume and distribution over time and compare computed tomography (CT) with pulmonary function tests for determining... ...

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        Absence of germline mutations in BAP1 in sporadic cases of malignant mesothelioma

        Malignant mesothelioma (MM) is a uniformly fatal tumour caused predominantly by exposure to asbestos. ...

        Research

        Rare childhood cancers—an increasing entity requiring the need for global consensus and collaboration

        Rare childhood cancers have not benefited to the same extent from the gains that have been made for their frequently occurring counterparts. ...

        Research

        Adult digit ratio (2D:4D) is not related to umbilical cord androgen or estrogen concentrations, their ratios or net bioactivity

        Ratio of second digit length to fourth digit length (2D:4D) has been extensively used in human and experimental research as a marker of fetal sex steroid... ...

        Research

        Identifying families most likely to have missing paternal details in birth registrations using linked data

        The purpose of this study was to determine the extent of missing paternal data in birth registrations and the characteristics of families most likely to have... ...

        Research

        Reduced immune responses in chimeric mice engrafted with bone marrow cells from mice with airways inflammation.

        During respiratory inflammation, it is generally assumed that dendritic cells differentiating from the bone marrow are immunogenic rather than immunoregulatory. ...

        Research

        Parent voices guide smoking intervention development

        While parents' influence on their children's smoking behaviour is widely recognised, little is known about parents of four to eight year olds' attitudes and... ...

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