AEC-conditioned DC showed selective upregulation of chemokines that recruit Th1 cells, but minimal change in chemokines linked to Th2 cell recruitment. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2012
• January 2012

Probiotics are beneficial bacteria which help premature babies by improving milk feed tolerance and reducing the risk of a life-threatening gut condition known as necrotizing enterocolitis.  The optimal type and dose of probiotic for sick term and ...

• 1. Telethon Kids Institute
• Our research
• Past teams
• Neonatal Neurodevelopment, Gut Health and Nutrition

The carcinogenic liver fluke Opisthorchis viverrini is a major public health problem in the Mekong basin region. The liver flukes can induce cholangiocarcinoma, a bile duct cancer that causes a significant burden of mortality and economic loss. Various public health interventions have been conducted to reduce opisthorchiasis but the prevalence of O. viverrini remains high in endemic regions. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2022
• September 2022

Fetal exposure to maternal smoking during pregnancy is associated with the development of noncommunicable diseases in the offspring. Maternal smoking may induce such long-term effects through persistent changes in the DNA methylome, which therefore hold the potential to be used as a biomarker of this early life exposure. With declining costs for measuring DNA methylation, we aimed to develop a DNA methylation score that can be used on adolescent DNA methylation data and thereby generate a score for in utero cigarette smoke exposure. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2020
• September 2020

This is the first study to examine the associations between a range of blood micronutrient levels and DNA damage in healthy children. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2015
• July 2015

Human mobility is a driver for the reemergence or resurgence of malaria and has been identified as a source of cross-border transmission. However, movement patterns are difficult to measure in rural areas where malaria risk is high. In countries with malaria elimination goals, it is essential to determine the role of mobility on malaria transmission to implement appropriate interventions. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2022
• December 2022

We conducted a retrospective review for all cases of S aureus bacteremia and sterile site infections, for children under 15 years, in northern Australia over... ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2014
• March 2014

We systematically reviewed the published evidence for the developmental origins of health and disease hypothesis among aboriginal populations from Australia,... ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2012
• December 2012

Gina Trapp GT BHSc(Hons1A), RPHNutr, PhD ARC DECRA Fellow & Head of Food and Nutrition Research 0410 589 374 Gina.Trapp@telethonkids.org.au ARC DECRA Fellow & Head of Food and Nutrition Research Dr Gina Trapp is Head of Food and Nutrition Research ...

• 1. Telethon Kids Institute
• Projects

Breakdown of mitochondrial proteostasis activates quality control pathways including the mitochondrial unfolded protein response (UPRmt) and PINK1/Parkin mitophagy. However, beyond the up-regulation of chaperones and proteases, we have a limited understanding of how the UPRmt remodels and restores damaged mitochondrial proteomes.  ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2023
• September 2023

The human placenta is a rapidly developing transient organ that is key to pregnancy success. Early development of the conceptus occurs in a low oxygen environment before oxygenated maternal blood begins to flow into the placenta at ~10–12 weeks’ gestation. This process is likely to substantially affect overall placental gene expression. Transcript variability underlying gene expression has yet to be profiled. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2022
• May 2022

The intensity of transmission of Aedes-borne viruses is heterogeneous, and multiple factors can contribute to variation at small spatial scales. Illuminating drivers of heterogeneity in prevalence over time and space would provide information for public health authorities. The objective of this study is to detect the spatiotemporal clusters and determine the risk factors of three major Aedes-borne diseases, Chikungunya virus, Dengue virus, and Zika virus clusters in Mexico. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2022
• October 2022