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        157-168 of 440 results for 'origins'

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        Dysregulation of innate immunity in ulcerative colitis patients who fail anti-tumor necrosis factor therapy

        Study the innate immune function in ulcerative colitis patients who fail to respond to anti-tumor necrosis factor therapy ...

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        World Allergy Organization-McMaster University Guidelines for Allergic Disease Prevention (GLAD-P): Probiotics

        Prevalence of allergic diseases in infants, whose parents and siblings do not have allergy, is approximately 10% and reaches 20-30% in those with an allergic... ...

        Research

        T-cell activation genes differentially expressed at birth in CD4+ T-cells from children who develop IgE food allergy

        To show underlying mechanisms, we examined differences in T-cell gene expression in samples at birth and at 1 year in children with and without IgE allergy. ...

        Research

        A novel role for interleukin-1 receptor signaling in the developmental regulation of immune responses to endotoxin

        Suggests that IL-1R1 expression provides an additional level of Myd88-dependent signaling during this period of heighted susceptibility to infection. ...

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        The relationship between maternal folate status in pregnancy, cord blood folate levels, and allergic outcomes in early childhood

        This study examined whether maternal and/or fetal folate status in pregnancy is associated with infant allergic outcomes. ...

        Research

        Mums Minds Matter

        Amy Jenny Susan Desiree Keerthi Finlay-Jones Downs Prescott Silva Kottampally AFJ JA SL DS KK BPsych(Hons), MPsych(Clinical), MHealthEcon, PhD (Clin Psych) BApplSci (physio) MSc PhD MBBS BMedSci PhD FRACP MBBS, FRACP, MPH, PhD Bsc (Hons), ...

        Research

        Genetic and environmental factors in the aetiology of hypospadias

        The increasing use of assisted reproductive techniques and hormonal manipulation during pregnancy may have been associated with an apparent rise in the... ...

        Research

        Impact of the Reelin signaling cascade (Ligands-Receptors-Adaptor Complex) on cognition in schizophrenia

        Our previous neurocognitive studies of schizophrenia outlined two clusters of affected subjects-cognitively spared (CS) and cognitive deficit (CD), the... ...

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        Epigenomic variability is associated with age-specific naïve CD4 T cell response to activation in infants and adolescents

        Childhood is a critical period of immune development. During this time, naïve CD4 T cells undergo programmed cell differentiation, mediated by epigenetic changes, in response to external stimuli leading to a baseline homeostatic state that may determine lifelong disease risk. However, the ontogeny of epigenetic signatures associated with CD4 T cell activation during key developmental periods are yet to be described. ...

        Research

        Study protocol of a multicentre, randomised, controlled trial evaluating the effectiveness of probiotic and peanut oral immunotherapy in inducing desensitisation or tolerance in children with peanut allergy compared with oral immunotherapy

        Peanut allergy is the the most common cause of life-threatening food-induced anaphylaxis. There is currently no effective long-term treatment. There is a pressing need for definitive treatments that improve the quality of life and prevent fatalities. ...

        Research

        Expert consensus document: The International Scientific Association for Probiotics and Prebiotics (ISAPP) consensus statement on the definition and scope of prebiotics

        In December 2016, a panel of experts was convened by the International Scientific Association for Probiotics an Prebiotics to review the scope of prebiotic. ...

        Research

        Cohort profile of the HealthNuts study: Population prevalence and environmental/genetic predictors of food allergy

        HealthNuts is a single-centre, multi-wave, population-based longitudinal study designed to assess prevalence, determinants, natural history and allergy... ...

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