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        Pre-and Postnatal Vitamin D Status and Allergy Outcomes in Early Childhood

        The dramatic increase in the prevalence of allergic disease in recent decades reflects environmental and behavioural changes that have altered patterns of early immune development. The very early onset of allergic diseases points to the specific vulnerability of the developing immune system to environmental changes and the development of primary intervention strategies is crucial to address this unparalleled burden. ...

        Research

        Post tuberculosis disability

        Kefyalew Alene KA BSc, MPH, PhD Head, Geospatial and Tuberculosis 0404705064 Kefyalew.alene@telethonkids.org.au Honorary Research Fellow Dr Kefyalew Alene is a spatial epidemiologist working on infectious diseases including tuberculosis in low- and ...

        Research

        Airway smooth muscle thickness and contraction are enhanced by intra-amniotic lipopolysaccharide in an ovine model of premature birth

        Abnormalities of the airway smooth muscle (ASM) layer in asthma may develop before birth. We hypothesize that antenatal inflammation causes physiological abnormalities of the ASM that predisposes asthma. This study determined the short-term effects of antenatal inflammation on the developing ASM. ...

        Research

        Severe winter asthma exacerbations can be prevented by omalizumab, but there is no carryover effect.

        Recurrent severe asthma exacerbations are associated with decreased lung growth or accelerated loss of long function and add substantially to cost and morbidity ...

        Research

        Ventilatory response and stability of oxygen saturation during a hypoxic challenge in very preterm infants

        Preterm infants have immature control of breathing and impaired pulmonary gas exchange. We hypothesized that infants with bronchopulmonary dysplasia (BPD) have a blunted ventilatory response and peripheral oxygen saturation (SpO2 ) instability during a hypoxic challenge. ...

        Research

        Pre-existing differences in mothers of children with Autism Spectrum disorder and/or intellectual disability: A review

        The aim of this study is to review research on the pre-existing characteristics which differentiate mothers of children with ASD and/or ID of unknown cause... ...

        Research

        Vitamin D deficiency causes deficits in lung function and alters lung structure

        The prevalence of vitamin D deficiency is increasing and has been linked to obstructive lung diseases including asthma and chronic obstructive pulmonary disease ...

        Research

        School Built Environments and Bullying Behaviour: A Conceptual Model Based on Qualitative Interviews

        Interest in how the school built environment impacts bullying behaviour has gained momentum in recent years. While numerous studies have identified locations within schools where bullying frequently occurs, few studies have investigated the potential conceptual pathways linking school locations to bullying behaviour. ...

        Research

        Australian First Nations response to the pandemic: A dramatic reversal of the ‘gap’

        Until the recent death in Dubbo of an Aboriginal man, there have been no deaths from Covid 19 in Australia. The extraordinary success of Aboriginal and Torres Strait Islander populations in controlling the effects of this pandemic has been a global role model. ...

        Research

        The COSI-2 Trial

        Tobias Jenny Strunk Mountain TS JM MD, PhD, FRACP MBA MClinEpi Head, Neonatal Health Program Manager, Neonatal Health / Protect Trial tobias.strunk@telethonkids.org.au Head, Neonatal Health Clinical Professor Tobias Strunk is a Consultant ...

        Research

        A CHAF1B-Dependent Molecular Switch in Hematopoiesis and Leukemia Pathogenesis

        Here we report that CHAF1B is required for normal hematopoiesis while its overexpression promotes leukemia ...

        Research

        Mapping Lung Hematopoietic Progenitors: Developmental Kinetics and Response to Influenza A Infection

        The bone marrow is a specialised niche responsible for the maintenance of hematopoietic stem and progenitor cells during homeostasis and inflammation. Recent studies however have extended this essential role to the extramedullary and extravascular lung microenvironment. Here, we provide further evidence for a reservoir of hematopoietic stem and progenitor cells within the lung from embryonic day 18.5 until adulthood. ...

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