Maternal stressful life events during pregnancy have been associated with immune dysregulation and increased risk for asthma and atopy in offspring. Few studies have investigated whether prenatal stress is associated with increased overall or specific infectious diseases in childhood, nor explored sex differences. We sought to examine the relationship between the nature and timing of maternal stress in pregnancy and hospitalisation with infection in offspring. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2021
• January 2021

It is plausible that dog-facilitated activity rather than dog ownership per se encourages children's physical activity behaviors. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2014
• October 2014

Here we describe a method by which serial biopsy can be used to validate response to dacomitinib treatment in vivo using a mouse glioblastoma model ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2017
• April 2017

Fiona Stanley FJ FAA FASSA MSc MD FFPHM FAFPHM FRACP FRANZCOG HonDSc HonDUniv HonFRACGP HonMD HonFRCPCH HonLLB (honoris causa) Patron 08 6319 1176 contact@telethonkids.org.au Patron Named Australian of the Year in 2003, Professor Fiona Stanley is a ...

• Telethon Kids Institute
• Our research
• Early Environment
• Developmental Origins of Child Health
• Expired projects

Medulloblastoma is the most common malignant childhood brain tumor, and 5-year overall survival rates are as low as 40% depending on molecular subtype, with new therapies critically important. As radiotherapy and chemotherapy act through the induction of DNA damage, the sensitization of cancer cells through the inhibition of DNA damage repair pathways is a potential therapeutic strategy. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2021
• April 2021

Medulloblastoma, the most common pediatric malignant brain tumor, consists of at least four distinct molecular subgroups. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2015
• February 2015

HealthNuts is a single-centre, multi-wave, population-based longitudinal study designed to assess prevalence, determinants, natural history and allergy... ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2015
• January 2015

Brain tumors presenting in infancy, especially during the first 6 months of life. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2012
• September 2012

To determine the constellation of lifestyle and demographic factors that are associated with poor mental health in an adolescent population. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2011
• January 2011

With improvement in leukemia therapy, central nervous system (CNS) tumors are the leading cause of cancer mortality in children and the most expensive... ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2011
• January 2011

The P2X7R is highly expressed on the macrophage cell surface, and activation of infected cells by extracellular ATP has been shown to kill intracellular bacte ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2010
• June 2010

Hereditary cancer predisposition syndromes (HCPS) account for at least 10% of paediatric cancers.1 Li‐Fraumeni syndrome (LFS) is a dominant HCPS caused by mutations in the TP53 gene and is associated with an 80–90% lifetime risk of cancer, commencing in infancy.2 Children of affected individuals are at 50% risk of inheriting the family mutation. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2021
• March 2021