QuantSeq, coupled with a fast quantification method such as Salmon, should provide a viable alternative to traditional RNA-Seq in many applications ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2019
• December 2019

Repeated video instruction over time improves inhaler technique in young children ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2016
• January 2016

Patients with comorbid asthma-obesity experience greater disease severity and are less responsive to therapy. We have previously reported adipose tissue within the airway wall that positively correlated with body mass index. Accumulation of biologically active adipose tissue may result in the local release of adipokines and disrupt large and small airway function depending on its anatomical distribution. This study therefore characterized airway-associated adipose tissue distribution, lipid composition, and adipokine activity in a porcine model. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2023
• February 2023

In this review, we discuss recent mechanistic studies casting further light on how the expression of sex hormones may influence the innate and adaptive immune system ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2018
• May 2018

The pathogenesis of asthma continues to be a major topic of interest to our authors with reviews and original papers on the role of viruses, mechanisms of... ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2015
• January 2015

Excessive production, secretion, and retention of abnormal mucus is a pathological feature of many obstructive airways diseases including asthma. Azithromycin is an antibiotic that also possesses immunomodulatory and mucoregulatory activities, which may contribute to the clinical effectiveness of azithromycin in asthma. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2022
• May 2022

Ingrid Anthony Deborah Jonatan Thomas Laing Kicic Strickland Leffler Iosifidis IL A DH JL TI BSc PhD BSc (Hons) PhD PhD PhD BSc BMedSci(Hons) PhD Head, Children's Respiratory Science Rothwell Family Fellow; Head, Airway Epithelial Research Program ...

• 1. Telethon Kids Institute
• Projects

This paper is an editorial comment by Professor Patrick Holt on the potential for developing early intervention strategies in children with allergies and asthma ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2014
• February 2014

Rhinovirus (RV) C can cause asymptomatic infection and respiratory illnesses ranging from the common cold to severe wheezing. The aim was to identify how age and other individual-level factors are associated with susceptibility to RV-C illnesses. Longitudinal data from the COAST (Childhood Origins of Asthma) birth cohort study were analyzed to determine relationships between age and RV-C infections. Neutralizing antibodies specific for RV-A and RV-C (three types each) were determined using a novel PCR-based assay. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2021
• April 2021

The objectives of this document are to highlight aspects of mite biology that are clinically relevant and to update the current knowledge on mite allergens ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2017
• April 2017

The developing immune system and allergy ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2010
• January 2010

We recruited age- and sex-matched Chinese immigrants living in Western Australia for less than 6 months (newly arrived, n = 22) or more than 5 years. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2018
• April 2018