Allergic inflammation is commonly observed in a number of conditions that are associated with atopy including asthma, eczema and rhinitis. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2012
• September 2012

The airway epithelium forms a highly regulated physical barrier that normally prevents invasion of inhaled pathogens and allergens from the airway lumen. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2011
• July 2011

Vitamin D has been linked in some studies with atopy- and asthma-associated phenotypes in children with established disease,but its role in disease inception... ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2011
• May 2011

The hallmark of atopic asthma is transient airways hyperresponsiveness (AHR) preceded by aeroallergen-induced Th-cell activation. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2011
• January 2011

Bacterial colonisation of the airways is associated with increased risk of childhood asthma ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2010
• September 2010

This study aimed to investigate the effects of different macro-environments on asthma genotype-phenotype associations in 2 geographically separated populations ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2010
• February 2010

Anti-viral innate immune responses may be impaired in asthma, although the mechanisms are not well understood. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2010
• January 2010

Pat Deborah Holt Strickland PG DH PhD, DSc, FRCPath, FRCPI, FAA PhD Emeritus Honorary Researcher Program Head, Immunobiology and Immunotherapeutic Program Patrick.Holt@telethonkids.org.au Deb.Strickland@telethonkids.org.au Emeritus Honorary ...

• 1. Telethon Kids Institute
• Our research
• Past teams
• Human Immunology

Recently, "Technical standards for respiratory oscillometry" was published, which reviewed the physiological basis of oscillometric measures and detailed the technical factors related to equipment and test performance, quality assurance and reporting of results. Here we present a review of the clinical significance and applications of oscillometry. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2022
• February 2022

Studies examining associations of early-life cat and dog ownership with childhood asthma have reported inconsistent results. Several factors could explain these inconsistencies, including type of pet, timing, and degree of exposure. Our aim was to study associations of early-life cat and dog ownership with asthma in school-aged children, including the role of type (cat vs dog), timing (never, prenatal, or early childhood), and degree of ownership (number of pets owned), and the role of allergic sensitization. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2022
• February 2022

Recent evidence suggests that parental exposures before conception can increase the risk of asthma in offspring. We investigated the association between parents' preconception body mass index (BMI) trajectories from childhood to adolescence and subsequent risk of asthma in their offspring. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2022
• January 2022

Asthma is the most common chronic lung disease in childhood. There has been a significant worldwide effort to develop tools/methods to identify children's risk for asthma as early as possible for preventative and early management strategies. Unfortunately, most childhood asthma prediction tools using conventional statistical models have modest accuracy, sensitivity, and positive predictive value. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2021
• June 2021