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        Targeting cytokine- and therapy-induced PIM1 activation in preclinical models of T-cell acute lymphoblastic leukemia and lymphoma

        IL7 and glucocorticoids coordinately drive aberrant activation of PIM1 and suggests that T-ALL and T-LBL patients could benefit from PIM inhibition ...

        Research

        Efficacy of oral amoxicillin-clavulanate or azithromycin for non-severe respiratory exacerbations in children with bronchiectasis (BEST-1)

        Amoxicillin-clavulanate treatment is beneficial in terms of resolution of non-severe exacerbations of bronchiectasis in children ...

        Research

        Gain of chromosome 21 in hematological malignancies: lessons from studying leukemia in children with Down syndrome

        Structural and numerical alterations of chromosome 21 are extremely common in hematological malignancies. While the functional impact of chimeric transcripts from fused chromosome 21 genes such as TEL-AML1, AML1-ETO, or FUS-ERG have been extensively studied, the role of gain of chromosome 21 remains largely unknown. ...

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        Pregnancy Induces a Steady-State Shift in Alveolar Macrophage M1/M2 Phenotype That Is Associated With a Heightened Severity of Influenza Virus Infection

        Pregnancy is associated with an alternatively activated phenotype of alveolar macrophage before infection ...

        Research

        The effect of upgrades to childcare outdoor spaces on preschoolers’ physical activity: Findings from a natural experiment

        This natural experiment investigated the influence of early childhood education and care outdoor physical environment upgrade on preschoolers' physical activity ...

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        Elevated IL-5 and IL-13 responses to egg proteins predate the introduction of egg in solid foods in infants with eczema

        Elevated egg-specific Th2 cytokine responses were established prior to egg ingestion at 4months and were not significantly altered by introduction of egg ...

        Research

        Management of oral and dental problems in Rett syndrome: a narrative review of the literature

        Review of the available dental literature on assessment and management of the oral manifestations of Rett syndrome ...

        Research

        A microbiome case-control study of recurrent acute otitis media identified potentially protective bacterial genera

        We characterised the nasopharyngeal microbiome of these children in comparison to children with rAOM to identify potentially protective bacteria. ...

        Research

        A Prospective Ultrasound Study of Prenatal Growth in Infant Siblings of Children With Autism

        Identified no significant differences between the high- and low-risk fetuses in the rate of prenatal head and body growth throughout the 2nd and 3rd-trimester ...

        Research

        Maternal Alcohol Use Disorder and Risk of Child Contact with the Justice System in Western Australia: A Population Cohort Record Linkage Study

        Children who were exposed to a maternal alcohol use disorder had significantly increased odds of contact with the justice system. ...

        Research

        Impact of adolescent peer aggression on later educational and employment outcomes in an Australian cohort

        This study used prospective birth cohort data to analyse the relationship between peer aggression at 14 years of age and educational and employment outcomes... ...

        Research

        Vitamin D over the first decade and susceptibility to childhood allergy and asthma

        We aimed to research relationships between 25(OH)D levels from birth to 10 y/o and susceptibility to allergic sensitization, respiratory issues and asthma. ...

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