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        1789-1800 of 1817 results for 'early childhood/'

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        Rationale and methods of a randomized controlled trial of immunogenicity, safety and impact on carriage of pneumococcal conjugate and polysaccharide vaccines in infants in Papua New Guinea

        Vaccination trials in high endemicity areas are needed to provide evidence and guidance on idea strategies to protect children in these areas against infections ...

        Research

        Antifungal use in children with acute leukaemia: state of current evidence and directions for future research

        Invasive fungal disease (IFD) remains a common and serious complication in children treated for leukaemia. Antifungal prescription in children with leukaemia presents unique challenges, particularly due to variation in IFD risk between and within leukaemia treatment protocols, drug toxicities and interactions between antifungals and chemotherapeutic agents. ...

        Research

        The bone marrow microenvironment of pre-B acute lymphoblastic leukemia at single-cell resolution

        The bone marrow microenvironment (BMM) plays a key role in leukemia progression, but its molecular complexity in pre-B cell acute lymphoblastic leukemia (B-ALL), the most common cancer in children, remains poorly understood. To gain further insight, we used single-cell RNA sequencing to characterize the kinetics of the murine BMM during B-ALL progression. ...

        Research

        Amped Out: An Energy Drink Study

        Gina Matt Francis Trapp Cooper Mitrou GT MC FG BHSc(Hons1A), RPHNutr, PhD BCA Marketing, BSc Statistics and Applied Statistics, PhD BEc ARC DECRA Fellow & Head of Food and Nutrition Research Manager, Biometrics Program Head, Population Health, and ...

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        Clinical predictors of hypoxic pneumonia in children from the Eastern Highlands Province, Papua New Guinea: secondary analysis of two prospective observational studies

        Pneumonia is the leading cause of death in young children globally and is prevalent in the Papua New Guinea highlands. We investigated clinical predictors of hypoxic pneumonia to inform local treatment guidelines in this resource-limited setting. ...

        Research

        Kids are not small adults, Identifying age-dependent drug targets in paediatric oncology

        Omar Merridee Sébastien Laurence Rishi Sury Terrance Timo Raelene W. Joost Elaskalani Wouters Malinge Cheung Kotecha Johns Lassmann Endersby Lesterhuis OE MW SM LC RS T T R WJL BSc, MSc, PhD Bsc Hons (Physics), PhD PhD BPharm (Hons) MBA PhD MB ChB ( ...

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        Defining the microbes in the middle ear and upper respiratory tract that lead to recurrent ear infections – a metagenomic study

        Sarra Timo Christopher Lea-Ann Ruth Deborah Jamieson Lassmann Blyth Kirkham Thornton Lehmann SE T CC LK RT D BSc (Hons) MSc PhD BSc (Hons) MSc PhD MBBS (Hons) DCH FRACP FRCPA PhD PhD PhD AO, MBBS, MSc Senior Research Fellow Feilman Fellow; Program ...

        Research

        Left ventricular remodelling in rheumatic heart disease – trends over time and implications for follow-up in childhood

        Rheumatic heart disease (RHD) is the most common form of acquired heart disease worldwide. In RHD, volume loading from mitral regurgitation leads to left ventricular (LV) dilatation, increased wall stress, and ultimately LV dysfunction. Improved understanding of LV dynamics may contribute to refined timing of intervention. ...

        Research

        Immunisation

        Immunisation is the most effective way of protecting your child against a range of serious illnesses, including measles, hepatitis B and whooping cough. All vaccines used in Australia undergo stringent testing and ongoing monitoring. ...

        Research

        Bronchiolitis

        Bronchiolitis is a respiratory infection, usually occurring in babies under six months of age. It causes them to wheeze and can lead to pneumonia. Researchers are focusing on vaccines against the virus which commonly causes it. ...

        Research

        Lack of effectiveness of 13-valent pneumococcal conjugate vaccination against pneumococcal carriage density in Papua New Guinean infants

        Papua New Guinea (PNG) introduced the 13-valent pneumococcal conjugate vaccine (PCV13) in 2014, with administration at 1, 2, and 3 months of age. PCV13 has reduced or eliminated carriage of vaccine types in populations with low pneumococcal carriage prevalence, carriage density and serotype diversity. ...

        Research

        Dedicated paediatric Outpatient Parenteral Antimicrobial Therapy medical support: a pre-post observational study

        We examined the impact of introducing a dedicated team to OPAT, to define the role of increased medical oversight in improving patient outcomes in this cohort. ...

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