Children with Down syndrome (constitutive trisomy 21) that develop acute lymphoblastic leukemia (DS-ALL) have a 3-fold increased likelihood of treatment-related mortality coupled with a higher cumulative incidence of relapse, compared with other children with B-cell acute lymphoblastic leukemia (B-ALL). ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2020
• July 2020

Medulloblastoma (MB) is the most common malignant brain tumor in children and a leading cause of cancer-related mortality and morbidity. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2011
• September 2011

Children with Down syndrome (DS, trisomy 21) are at a significantly higher risk of developing acute leukemia compared to the overall population. Many studies investigating the link between trisomy 21 and leukemia initiation and progression have been conducted over the last two decades. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2023
• October 2023

Acute erythroleukemia (AEL or acute myeloid leukemia [AML]-M6) is a rare but aggressive hematologic malignancy. Previous studies showed that AEL leukemic cells often carry complex karyotypes and mutations in known AML-associated oncogenes. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2020
• August 2020

In this study, we investigate the in vivo synergy between romidepsin and cytarabine ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2019
• July 2019

In this. i study the MTD and RP2D, safety, PK, and preliminary activity of single-agent ribociclib were investigated in patients with neuroblastoma. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2017
• May 2017

The NUT midline carcinoma (NMC) is a rare but fatal cancer for which systematic testing of therapy options has never been performed. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2014
• February 2014

Cancers in children are very different from cancers in adults - in most cases they appear to strike simply at random. They also develop differently and can spread more rapidly and aggressively. And because cancers in children are not obviously linked to their lifestyles, much work is needed to pinpoint their cause. ...

• Telethon Kids Institute
• Our research
• Research Topics

Raelene Nick Endersby Gottardo R NG BSc (Hons) PhD MBChB FRACP PhD Brainchild Fellow; Co-Head, Brain Tumour Research Co-Head, Brain Tumour Research raelene.endersby@telethonkids.org.au nicholas.gottardo@telethonkids.org.au Co-Head, Brain Tumour ...

• Telethon Kids Institute
• Projects

Undescended testes is associated with an increased risk of testicular cancer and male infertility, and decreased paternity ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2018
• October 2018

Childhood brain tumors (CBT) are the leading cause of cancer death in children; their risk factors are still largely unknown. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2012
• June 2012

Esophageal squamous cell carcinoma (ESCC) is a prevalent malignant tumor of the digestive tract with a low 5-year survival rate due to the lack of effective treatment methods. Although therapeutic monoclonal antibodies (mAbs) now play an important role in cancer therapy, effective targeted mAbs are still lacking for ESCC.  ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2023
• December 2023