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        Prevention of bacterial complications of scabies using mass drug administration: A population-based, before-after trial in Fiji, 2018–2020

        Scabies is an important predisposing factor of impetigo which can lead to serious bacterial complications. Ivermectin-based mass drug administration can substantially reduce scabies and impetigo prevalence in endemic settings, but the impact on serious bacterial complications is not known. ...

        Research

        Comparison of group A streptococcal titres in healthy children and those with pharyngitis and skin infections

        Rates of acute rheumatic fever, a sequelae of group A Streptococcal (GAS) infection, remain unacceptably high in Indigenous Māori and Pacific children in New Zealand. This prospective study aimed to describe GAS antibody titres in healthy children (5–14 years) by ethnicity, and to determine how paired titres vary with GAS culture positive and negative pharyngitis, and GAS skin infections. ...

        Research

        Burden of cardiovascular diseases in the Eastern Mediterranean Region, 1990-2015: findings from the Global Burden of Disease 2015 study

        The age-standardized disability-adjusted life years rates in the Eastern Mediterranean Region are considerably higher than the global average. ...

        Research

        Scabies and risk of skin sores in remote Australian Aboriginal communities: A self-controlled case series study

        The association between scabies and skin sores is highly significant and indicates a causal relationship ...

        Research

        Group A Streptococcus M1T1 Intracellular Infection of Primary Tonsil Epithelial Cells Dampens Levels of Secreted IL-8 Through the Action of SpyCEP

        Our results suggest that intracellular infection with the pathogenic GAS M1T1 clone induces a strong pro-inflammatory response in primary tonsil epithelial cells ...

        Research

        Dedicated paediatric Outpatient Parenteral Antimicrobial Therapy medical support: a pre-post observational study

        We examined the impact of introducing a dedicated team to OPAT, to define the role of increased medical oversight in improving patient outcomes in this cohort. ...

        Research

        Ascertaining infectious disease burden through primary care clinic attendance among young Aboriginal children living in four remote communities in Western Australia

        Improved public health measures targeting bacterial skin infections are needed to reduce this high burden of skin infections in Western Australia ...

        Research

        The NICE-GUT trial protocol: A randomised, placebo controlled trial of oral nitazoxanide for the empiric treatment of acute gastroenteritis among Australian Aboriginal children

        Diarrhoeal disease is the second leading cause of death in children under 5 years globally, killing 525 000 annually. Australian Aboriginal and Torres Strait Islander (hereafter Aboriginal) children suffer a high burden of disease. ...

        Research

        How many doses make a difference? An analysis of secondary prevention of rheumatic fever and rheumatic heart disease

        increased adherence to penicillin prophylaxis is associated with reduced acute rheumatic fever recurrence and a likely reduction in mortality ...

        Research

        Epidemiology of intussusception before and after rotavirus vaccine introduction in Fiji

        The incidence of intussusception pre-rotavirus vaccine in Fiji is low ...

        Research

        Are scabies and impetigo “normalised”? A cross-sectional comparative study of hospitalised children in northern Australia assessing clinical recognition

        Scabies and impetigo infections are under-recognised and hence under-treated by clinicians ...

        Research

        A systematic and functional classification of Streptococcus pyogenes that serves as a new tool for molecular typing and vaccine development.

        This publication is a systematic analysis of all Group A Streptococcus M protein variants, to assist in the development of a vaccine. ...

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