Although antenatal influenza vaccination is an important public health intervention for preventing serious infection in pregnant women and newborns, reported... ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2016
• January 2016

Asha Janessa Tim Bowen Pickering Barnett AC Dr TB BA MBBS DCH FRACP PhD GAICD OAM BSc PhD PhD Head, Healthy Skin and ARF Prevention Senior Research Fellow (currently HOT NORTH Early Career Fellow) Head of the Strep A Pathogenesis & Diagnostics team, ...

• Telethon Kids Institute
• Projects

Evidence suggests that children who had received an initial priming dose of whole-cell pertussis (wP) vaccine, rather than acellular pertussis (aP) vaccine, had a lower risk of developing IgE-mediated food allergy, the most common cause of anaphylaxis-related hospital presentations of childhood. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2024
• January 2024

The Staphylococcus aureus Network Adaptive Platform (SNAP) trial is a multifactorial Bayesian adaptive platform trial that aims to improve the way that S. aureus bloodstream infection, a globally common and severe infectious disease, is treated. In a world first, the SNAP trial will simultaneously investigate the effects of multiple intervention modalities within multiple groups of participants with different forms of S. aureus bloodstream infection. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2023
• December 2023

Respiratory syncytial virus (RSV) reinfection in children is poorly understood. We examined the incidence, characteristics, and outcomes of hospital-attended RSV reinfections in children <16 years in Western Australia between 2012 and 2022. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2023
• December 2023

Despite several calls for greater inclusion of pregnant people in non-obstetric clinical trials, their systematic exclusion remains common practice. Excluding pregnant individuals from clinical trials may result in unintended consequences such as inadequate treatment of medical conditions in pregnancy, inappropriate dosing of medications, and investigational therapies being used off-label outside of the context of a clinical trial, risking adverse events in the absence of demonstrated efficacy. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2023
• March 2023

Antenatal inactivated influenza and pertussis-containing vaccines offer protection against severe respiratory infections for pregnant women and infants <6 months of age. Both vaccines are recommended in pregnancy; however, little is known about temporal or jurisdictional trends and predictors of uptake. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2023
• February 2023

For decades, the research community has called for participant information sheets/consent forms (PICFs) to be improved. Recommendations include simplifying content, reducing length, presenting information in layers and using multimedia. However, there are relatively few studies that have evaluated health consumers' (patients/carers) perspectives on the type and organisation of information, and the level of detail to be included in a PICF to optimise an informed decision to enter a trial. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2022
• December 2022

Staphylococcus aureus bloodstream (SAB) infection is a common and severe infectious disease, with a 90-day mortality of 15%-30%. Despite this, <3000 people have been randomized into clinical trials of treatments for SAB infection. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2022
• November 2022

Contemporary data for the global burden of sore throat and group A Streptococcus (Strep A) pharyngitis are required to understand the frequency of disease and develop value propositions for Strep A vaccines. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2022
• May 2022

Parainfluenza viruses are significant contributors to childhood respiratory illness worldwide, although detailed epidemiological studies are lacking. Few recent Australian studies have investigated serotype-specific PIV epidemiology, and there is a paucity of southern hemisphere PIV reports. We report age-stratified PIV hospitalisation rates and a mathematical model of PIV seasonality and dynamics in Western Australia (WA). ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2021
• January 2021

Group A streptococcal (GAS) pharyngitis has traditionally been considered the sole precursor of acute rheumatic fever (ARF). Evidence from Australia, however, suggests that GAS skin infections may contribute to the pathogenesis of ARF. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2020
• November 2020