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        193-204 of 590 results for 'aboriginal respiratory'

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        Primary Nasal Epithelial Cells as a Surrogate Cell Culture Model for Type-II Alveolar Cells to Study ABCA-3 Deficiency

        ATP Binding Cassette Subfamily A Member 3 (ABCA-3) is a lipid transporter protein highly expressed in type-II alveolar (AT-II) cells. Mutations in ABCA3 can result in severe respiratory disease in infants and children. To study ABCA-3 deficiency in vitro, primary AT-II cells would be the cell culture of choice although sample accessibility is limited. Our aim was to investigate the suitability of primary nasal epithelial cells, as a surrogate culture model for AT-II cells, to study ABCA-3 deficiency. ...

        Research

        Epidemiology of Otitis Media hospitalisations in Western Australia: a retrospective population cohort study (1996-2012)

        Deborah Hannah Lehmann Moore D HC AO, MBBS, MSc OAM BSc (Hons) GradDipClinEpi PhD Honorary Emeritus Fellow Program Head, Infection and Vaccines 08 6319 1427 Hannah.moore@telethonkids.org.au Honorary Emeritus Fellow Program Head, Infection and ...

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        Genomic testing for children with interstitial and diffuse lung disease (chILD): parent satisfaction, understanding and health-related quality of life

        Research is needed to determine best practice for genomic testing in the context of child interstitial or diffuse lung disease. We explored parent's and child's health-related quality of life, parents' perceived understanding of a genomic testing study, satisfaction with information and the study and decisional regret to undertake genomic testing. ...

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        The SPEC score—A quantifiable CT scoring system for primary ciliary dyskinesia

        Structural lung changes seen on computed tomography scans in persons with primary ciliary dyskinesia are currently described using cystic fibrosis derived scoring systems. Recent work has shown structural changes and frequencies that are unique to PCD, indicating the need for a unique PCD-derived scoring system. ...

        Research

        Predicting long term lung health outcomes in young adults born very preterm (WALHIP 19 year old follow-up)

        Graham Shannon Elizabeth Hall Simpson Smith GL SS ES BAppSci PhD CRFS FANZSRS FThorSoc FERS BMedSci (hons), PhD PhD, MSc, BSc Honorary Research Associate Co-Head, Children's Lung Health; Senior Research Fellow Program Manager 08 6319 1631 08 6319 ...

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        Australian Aboriginal children with otitis media have reduced antibody titers to specific nontypeable Haemophilus influenzae vaccine antigens

        decreased serum IgG responses to NTHi outer membrane proteins may contribute to the development of chronic and severe OM in Australian Aboriginal children ...

        Research

        Variation in treatment preferences of pulmonary exacerbations among Australian and New Zealand cystic fibrosis physicians

        Despite advances in cystic fibrosis (CF) management and survival, the optimal treatment of pulmonary exacerbations remains unclear. Understanding the variability in treatment approaches among physicians might help prioritise clinical uncertainties to address through clinical trials. ...

        Research

        Improving the Diagnosis and Treatment of Paediatric Bronchiectasis Through Research and Translation

        Bronchiectasis, particularly in children, is an increasingly recognised yet neglected chronic lung disorder affecting individuals in both low-to-middle and high-income countries. It has a high disease burden and there is substantial inequity within and between settings. Furthermore, compared with other chronic lung diseases, considerably fewer resources are available for children with bronchiectasis.  ...

        Research

        Changing Prevalence of Lower Airway Infections in Young Children with Cystic Fibrosis

        Aspergillus species and P. aeruginosa are commonly present in the lower airways from infancy ...

        Research

        Determinants of early-life lung function in African infants

        To assess the determinants of early lung function in African infants. ...

        Research

        Monitoring disease progression in childhood bronchiectasis

        Bronchiectasis (not related to cystic fibrosis) is a chronic lung disease caused by a range of etiologies but characterized by abnormal airway dilatation, recurrent respiratory symptoms, impaired quality of life and reduced life expectancy. ...

        Research

        International links between Streptococcus pneumoniae vaccine serotype 4 sequence type (ST) 801 in Northern European shipyard outbreaks of invasive pneumococcal disease

        Pneumococcal disease outbreaks of vaccine preventable serotype 4 sequence type (ST)801 in shipyards have been reported in several countries. We aimed to use genomics to establish any international links between them. ...

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