Genotype-phenotype associations relating to bronchitis and allergy susceptibility are dependent on the environment ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2017
• July 2017

Anthony Stephen Kicic Stick A SM BSc (Hons) PhD MB BChir PhD MRCP FRACP Rothwell Family Fellow; Head, Airway Epithelial Research Head, P4 Respiratory Health for Kids Anthony.Kicic@telethonkids.org.au Rothwell Family Fellow; Head, Airway Epithelial ...

• 1. Telethon Kids Institute
• Projects

Most asthmatics would prefer workplaces, healthcare facilities, and environments that are fragrance-free, which could help reduce adverse effects ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2018
• January 2018

The developing immune system and allergy ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2010
• January 2010

There are well-described sex-based differences in how the immune system operates. In particular, cisgender (cis) females have a more easily activated immune system; associated with an increased prevalence of autoimmune diseases and adverse events following vaccinations. Conversely, cis males have a higher threshold for immune activation, and are more prone to certain infectious diseases, such as coronavirus disease (COVID-19). ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2022
• December 2022

The house dust mite (HDM) Dermatophagoides pteronyssinus is one of most important allergen sources and a major elicitor of allergic asthma. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2013
• January 2013

Neutrophils are the most abundant immune cell in circulation. However, due to a number of technical challenges for researchers, including the neutrophil's short lifespan and difficulties with preservation, they are often discarded during blood processing and thus ignored in cohort studies. As such, the contribution of neutrophils to disease and their involvement in disease mechanisms is less explored compared with other immune cell types. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2023
• February 2023

These data provide proof of concept supporting the rationale for developing transplacental immune reprogramming approaches for primary disease prevention ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2018
• November 2018

Poor maternal diet during pregnancy is a risk factor for severe lower respiratory infections in the offspring, but the underlying mechanisms remain elusive. Here, we demonstrate that in mice a maternal low-fiber diet led to enhanced LRI severity in infants because of delayed plasmacytoid dendritic cell recruitment and perturbation of regulatory T cell expansion in the lungs. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2023
• March 2023

Patients with systemic lupus erythematosus (SLE) have a decreased ability to clear cell remnants and multiple deficiencies in the ability to degrade cellular... ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2015
• January 2015

In the present study, we sought to evaluate the complement activation product C4d as a marker for lupus nephritis in systemic lupus erythematosus (SLE). ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2017
• December 2017

The burden of IgE-mediated food allergy in Australian born children is reported to be among the highest globally. This illness shares risk factors and frequently coexists with asthma, one of the most common noncommunicable diseases of childhood. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2021
• December 2021