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        Elastase Exocytosis by Airway Neutrophils Associates with Early Lung Damage in Cystic Fibrosis Children

        Protease elastase exocytosis by airway neutrophils occurs in all cystic fibrosis children, and its cellular measure correlates with early lung damage ...

        Research

        CF derived scoring systems do not fully describe the range of structural changes seen on CT scans in PCD

        Structural changes identified on CT scans in primary ciliary dyskinesia are not identical to those previously described in cystic fibrosis patients ...

        Research

        The prevalence of tuberculosis and malaria in minority indigenous populations of South- East Asia and the Western Pacific Region: a systematic review and meta-analysis

        Infectious diseases have been shown to disproportionately affect indigenous populations. Tuberculosis (TB) and malaria continue to impose a significant burden on humanity and are among the infectious diseases targeted within the 2030 Agenda for Sustainable Development. ...

        Research

        Matrix metalloproteinase activation by free neutrophil elastase contributes to bronchiectasis progression in early cystic fibrosis

        The aim of this study was to assess if MMP activation positively correlates with neutrophil elastase activity, disease severity and bronchiectasis in young... ...

        Research

        Reduced transforming growth factor β1 (TGF-β1) in the repair of airway epithelial cells of children with asthma

        Evidence into the role of TGF-β1 in airway epithelial repair in asthma is still controversial. This study tested the hypothesis that the reduced TGF-β1 levels previously observed in paediatric asthmatic airway epithelial cells directly contribute to the dysregulated repair seen in these cells. ...

        Research

        Early respiratory infection is associated with reduced spirometry in children with cystic fibrosis

        We hypothesized that the presence of these markers of cystic fibrosis lung disease in the first 2 years of life would be associated with reduced lung... ...

        Research

        Risk factors for bronchiectasis in children with cystic fibrosis

        We sought to determine risk factors for the onset of bronchiectasis, using data collected by the Australian Respiratory Early Surveillance Team for Cystic... ...

        Research

        Feasibility of parental collected nasal swabs for virus detection in young children with cystic fibrosis

        No evidence to demonstrate relationships with symptoms and viruses, prolonged symptoms, prolonged shedding or patterns of virus infections in CF ...

        Research

        Expression of bronchodilator response using forced oscillation technique measurements: absolute versus relative

        Expression of bronchodilator response using forced oscillation technique measurements: absolute versus relative ...

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