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        Innate Immune Responses and Gut Microbiomes Distinguish HIV-Exposed from HIV-Unexposed Children in a Population-Specific Manner

        In both high- and low-income countries, HIV-negative children born to HIV-positive mothers (HIV exposed, uninfected [HEU]) are more susceptible to severe infection than HIV-unexposed, uninfected (HUU) children, with altered innate immunity hypothesized to be a cause. Both the gut microbiome and systemic innate immunity differ across biogeographically distinct settings, and the two are known to influence each other. ...

        Research

        Consumption of energy drinks is associated with depression, anxiety, and stress in young adult males: Evidence from a longitudinal cohort study

        Energy drinks (EDs) claim to boost mental performance, however, few studies have examined the prospective effects of EDs on mental health. This study examined longitudinal associations between ED use and mental health symptoms in young adults aged 20 years over a 2-year period. ...

        Research

        Antibiotics or watchful waiting for acute otitis media in urban Aboriginal and Torres Strait Islander children?

        Chris Valerie Brennan-Jones Swift C VS PhD Head, Ear Health Aboriginal Co-Director, Djaalinj Waakinj Centre for Ear and Hearing Health; Aboriginal Cultural Guidance Advisor chris.brennan-jones@telethonkids.org.au Valerie.Swift@telethonkids.org.au ...

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        Risk of otitis media in offspring following maternal prenatal stress exposure

        There is limited but consistent evidence that suggests prenatal factors, including maternal stress, may contribute to susceptibility for otitis media. We aimed to determine the effect of multiple life stress events during pregnancy on risk of acute and recurrent otitis media in offspring at three and five years of age.  ...

        Research

        Understanding and optimising gratitude interventions: the right methods for the right people at the right time

        Gratitude has consistently been associated with various beneficial health-related outcomes, including subjective wellbeing, positive mental health, and positive physical health. In light of such effects, positive psychology researchers and practitioners have often implemented gratitude interventions in an attempt to build individuals' orientations toward appreciation and thankfulness. Recent meta-analyses and reviews have revealed, however, that these interventions often have mixed effects on gratitude or other health outcomes.  ...

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        Physicochemical compatibility of caffeine citrate and caffeine base injections with parenteral medications used in neonatal intensive care settings

        To investigate the physicochemical compatibility of caffeine citrate and caffeine base injections with 43 secondary intravenous drugs used in Neonatal Intensive Care Unit settings. ...

        Research

        Systematic chemical and molecular profiling of MLL-rearranged infant acute lymphoblastic leukemia reveals efficacy of romidepsin

        Identified romidepsin as a promising therapeutic for mixed lineage leukemia (MLL)-rearranged infant acute lymphoblastic leukemia ...

        Research

        Cohort profile: A population-based record linkage platform to address critical epidemiological evidence gaps in respiratory syncytial virus and other respiratory infections

        The Western Australia (WA) Respiratory Infections Linked Data Platform is a population-based cohort established to investigate the epidemiology of RSV and other respiratory infections in children aged 0-10 years, incorporating microbiological testing patterns, hospital admissions, emergency department presentations, and socio-demographic data. ...

        Research

        Standardization of Epidemiological Surveillance of Group A Streptococcal Impetigo

        Impetigo is a highly contagious bacterial infection of the superficial layer of skin. Impetigo is caused by group A Streptococcus (Strep A) and Staphylococcus aureus, alone or in combination, with the former predominating in many tropical climates. Strep A impetigo occurs mainly in early childhood, and the burden varies worldwide. It is an acute, self-limited disease, but many children experience frequent recurrences that make it a chronic illness in some endemic settings. ...

        Research

        Pathogens on the rise: is impaired immunity the cause of chronic ear and chest infections?

        Ruth Elke Peter Thornton Seppanen Richmond RT ES PC PhD BSc PhD MBBS MRCP(UK) FRACP Co-head, Bacterial Respiratory Infectious Disease Group (BRIDG) Program Manager, Bacterial Respiratory Infectious Disease Group Head, Vaccine Trials Group ...

        Research

        Data for policy

        Francis Joel Steve Mitrou Stafford Zubrick FG J SR BEc BA(Hons) MA PhD FASSA, FAAMHS, MSc AM PhD Program Head, Population Health, and Team Head, Human Development and Community Wellbeing Data Analyst Honorary Emeritus Research Fellow 08 6319 1499 08 ...

        Research

        Using continuous glucose monitoring to detect early dysglycaemia in children participating in the ENDIA study (Sub Protocol)

        Aveni Liz Haynes Davis AH EA BA (Hons), MBBChir, MA (Cantab), PhD MBBS FRACP PhD Senior Research Fellow Head, Chronic & Severe Diseases Research Focus Area; Clinical Lead, Diabetes and Obesity Research Aveni.Haynes@health.wa.gov.au Senior Research ...

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