Pre-clinical models that effectively recapitulate human disease are critical for expanding our knowledge of cancer biology and drug resistance mechanisms. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2010
• April 2010

Neonatal sepsis is a major cause of childhood mortality. Limited diagnostic tools and mechanistic insights have hampered our abilities to develop prophylactic or therapeutic interventions. Biomarkers in human neonatal sepsis have been repeatedly identified as associated with dysregulation of angiopoietin signaling and altered arachidonic acid metabolism.  ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2024
• May 2024

Acute Lymphoblastic Leukemia (ALL) occurring in the first year of life is rare. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2012
• September 2012

Glucose monitoring is vital in children with persistent hypoglycaemia to reduce the risk of adverse neuro-behavioural outcomes; especially in children with hyperinsulinism. The role of continuous glucose monitoring (CGM) systems in monitoring glucose levels in this cohort is limited. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2021
• September 2021

Invasive fungal infections are more common in children with high-risk acute lymphoblastic leukaemia and in relapsed disease ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2019
• October 2019

This retrospective population‐based study aimed to determine the incidence of type 2 diabetes from 2012 to 2019 in Western Australian youth aged under 16 years, and to examine temporal trends between 2000 and 2019, using data from the Western Australian Children’s Diabetes Database (WACDD). The data extracted for eligible patients diagnosed with type 2 diabetes, according to standard criteria, included diagnosis year, age, sex and self‐reported Aboriginal or Torres Strait Islander status. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2021
• February 2021

Due to global climate change–induced shifts in species distributions, estimating changes in community composition through the use of Species Distribution Models has become a key management tool. Being able to determine how species associations change along environmental gradients is likely to be pivotal in exploring the magnitude of future changes in species’ distributions. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2022
• January 2022

Melissa Fiona O'Donnell Stanley M FJ BPsych (Hons), MPsych, GradDip Ed, PhD FAA FASSA MSc MD FFPHM FAFPHM FRACP FRANZCOG HonDSc HonDUniv HonFRACGP HonMD HonFRCPCH HonLLB (honoris causa) Honorary Research Associate Patron 08 6319 1176 contact@ ...

• Telethon Kids Institute
• Projects

In-utero hyperglycemia exposure influences later cardiometabolic risk, although few studies include women with pre-existing type 2 diabetes (T2D) or assess maternal body mass index (BMI) as a potential confounder. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2023
• August 2023

Treatment options for viral lung infections are currently limited. We aimed to explore the safety and efficacy of inhaled ethanol in an influenza-infection mouse model. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2024
• April 2024

These observations suggest factors in the modern environment promote pancreatic islet autoimmunity and destruction of insulin-producing beta cells. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2013
• August 2013

The prevalence of overweight and obesity in children is a public health problem because of future morbidity. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2011
• February 2011