Shelley Prue Gorman Hart S PH BSc (Hons) PhD BSc (Hons) MSc PhD Honorary Research Associate Head, Inflammation shelley.gorman@telethonkids.org.au prue.hart@telethonkids.org.au Honorary Research Associate Head, Inflammation Shelley Gorman is a Group ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2010
• May 2010

Though exposure to air pollution has a detrimental effect on respiratory health, few studies have examined the association between elemental carbon exposure... ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2011
• February 2011

Severe dengue is a life-threatening complication; rapid identification of these cases, followed by adequate management is crucial to improve the clinical prognosis. Therefore, this study aimed to identify risk factors and predictors of severe dengue. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2021
• October 2021

Interleukin-10 is a key immunomodulatory cytokine the principal function of which is to limit the magnitude of immune response. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2011
• March 2011

Neutrophils are the most abundant immune cell in circulation. However, due to a number of technical challenges for researchers, including the neutrophil's short lifespan and difficulties with preservation, they are often discarded during blood processing and thus ignored in cohort studies. As such, the contribution of neutrophils to disease and their involvement in disease mechanisms is less explored compared with other immune cell types. ...

• 1. Telethon Kids Institute
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• Reports and Findings
• 2023
• February 2023

The house dust mite (HDM) Dermatophagoides pteronyssinus is one of most important allergen sources and a major elicitor of allergic asthma. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2013
• January 2013

The epidemic increase in the prevalence of allergic disease, which first started in the industrialized countries in the 1960s, may have reached a peak in the... ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2014
• August 2014

In this study, using a mouse model, we determined whether vitamin D deficiency in utero and during early life modulated the severity of asthma. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2012
• February 2012

As the rise in prevalence of allergic diseases worldwide corresponds in time with increasing infant vaccination, it has been hypothesized that childhood vaccination may increase the risk of allergic disease. We aimed to synthesize the literature on the association between childhood vaccination and allergy. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2021
• February 2021

Poor maternal diet during pregnancy is a risk factor for severe lower respiratory infections in the offspring, but the underlying mechanisms remain elusive. Here, we demonstrate that in mice a maternal low-fiber diet led to enhanced LRI severity in infants because of delayed plasmacytoid dendritic cell recruitment and perturbation of regulatory T cell expansion in the lungs. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2023
• March 2023

Patients with systemic lupus erythematosus (SLE) have a decreased ability to clear cell remnants and multiple deficiencies in the ability to degrade cellular... ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2015
• January 2015

There is increasing evidence that the functional state of the immune system at birth is predictive of the kinetics of immune maturation in early infancy. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2010
• April 2010