This paper reports on a five-year project to measure student wellbeing across an education system using the Middle Years Development Instrument ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2019
• June 2019

Inclusion of early child development in the United Nations Sustainable Development Agenda raises issues of how this goal should be monitored, particularly in low resource settings. The aim of this paper was to explore the validity of the early Human Capability Index (eHCI); a population measure designed to capture the holistic development of children aged 3-5 years. Convergent, divergent, discriminant and concurrent validity were examined by exploring the associations between eHCI domains and child (sex, age, stunting status, preschool attendance) and family (maternal education, home learning environment) characteristics. Analyses were repeated using data from seven low and middle income countries. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2020
• June 2020

Neonates have heightened susceptibility to infections. The biological mechanisms are incompletely understood but thought to be related to age-specific adaptations in immunity due to resource constraints during immune system development and growth. We present here an extended analysis of our proteomics study of peripheral blood-plasma from a study of healthy full-term newborns delivered vaginally, collected at the day of birth and on day of life (DOL) 1, 3, or 7, to cover the first week of life. The plasma proteome was characterized by LC-MS using our established 96-well plate format plasma proteomics platform. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2020
• October 2020

The recent increase in babies born with brain and eye malformations in Brazil is associated with Zika virus (ZIKV) infection in utero. ZIKV alters host DNA methylation in vitro. Using genome-wide DNA methylation profiling we compared 18 babies born with congenital ZIKV microcephaly with 20 controls. We found ZIKV-associated alteration of host methylation patterns, notably at RABGAP1L which is important in brain development, at viral host immunity genes MX1 and ISG15, and in an epigenetic module containing the causal microcephaly gene MCPH1. Our data support the hypothesis that clinical signs of congenital ZIKV are associated with changes in DNA methylation. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2021
• February 2021

The influence of the neighbourhood built environment on young children's physical development has been well-documented; however, there is limited empirical evidence of an association with social and emotional development. Parental perceptions of the neighbourhood built environment may act as facilitators or barriers to young children's play and interactions in their local environment. The aim of this study was to examine the associations between parents' perceptions of the neighbourhood built environment and the social-emotional development of children aged two-to-five years. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2022
• May 2022

Regular intramuscular (i.m.) benzathine penicillin G (BPG) injections have been the cornerstone of rheumatic heart disease (RHD) secondary prophylaxis since the 1950s. Patient adherence to IM BPG is poor, largely due to pain, the need for regular injections every 3-4 weeks and health sector delivery challenges in resource-limited settings. There is an urgent need for new approaches for secondary prophylaxis, such as an implant which could provide sustained penicillin concentrations for more than 6 months. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2023
• Jun 2023

Brain injury, resulting from stroke and traumatic brain injury, is a common occurrence in Australia, with Aboriginal people affected at a significant rate and impact felt by individuals, families and communities. Access to brain injury rehabilitation services for Aboriginal people is reported to be often limited, with very little support outside the hospital environment. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2021
• September 2021

Hayley Andrea Liz Phoebe Pulan Zino Christian Nathan Wenden George Bai Phiri HC AN LW P PB ZP BSc (1st Class Hons), PhD W.Aust. BHlthSc (hons), PhD BHlthSc MPH BSc(Neuro), MPH BSc, MPH BSc Program Head, Healthy Behaviours and Environments; National ...

• 1. Telethon Kids Institute
• Projects

This study aimed to derive and assess summary indices of three domains of the family environment, including a Family Stress Index, Home Education Index and Parenting Index ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2018
• June 2018

The New South Wales Child Development Study was established to enable a life course epidemiological approach to identifying risk and protective factors ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2018
• October 2018

A targeted program would have the potential to prevent one-quarter of the cases of being vulnerable on two or more AEDC domains at age five ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2016
• January 2016

Asha Jonathan Marianne Tim Bowen Carapetis AM Mullane Barnett AC JR MM TB BA MBBS DCH FRACP PhD GAICD AM MBBS FRACP FAFPHM PhD FAHMS BSc (OT) PhD Team Lead, Healthy Skin and ARF Prevention Executive Director; Head, Strep A Translation; Co-Founder of ...

• 1. Telethon Kids Institute
• Projects