B cells are critical to the development of multiple sclerosis (MS), but the mechanisms by which they contribute to the disease are poorly defined. We hypothesised that the expression of CD32b (FcγRIIb), a receptor for the Fc region of IgG with inhibitory activities in B cells, is lower on B cell subsets from people with clinically isolated syndrome (CIS) or MS. CD32b expression was highest on post-naive IgM+ B cell subsets in healthy controls. For females with MS or CIS, significantly lower CD32b expression was identified on IgM+ B cell subsets, including naive and IgMhi MZ-like B cells, when compared with control females. Lower CD32b expression on these B cell subsets was associated with detectable anti-Epstein Barr Virus viral capsid antigen IgM antibodies, and higher serum levels of B cell activating factor. To investigate the effects of lower CD32b expression, B cells were polyclonally activated in the presence of IgG immune complexes, with or without a CD32b blocking antibody, and the expression of TNF and IL-10 in B cell subsets was assessed. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2021
• January 2021

Terrance W. Joost Ben Johns Lesterhuis Wylie T WJL BW BSc PhD Honorary Research Associate Program Head, Cancer; Chronic and Severe Diseases RFA Deputy Head Research Fellow, Sarcoma Translation Research Joost.Lesterhuis@telethonkids.org.au ben.wylie@ ...

• 1. Telethon Kids Institute
• Projects

Maternal diet during pregnancy has long been recognised as an important determinant of neonatal outcomes and child development. Infant body composition is a potentially modifiable risk factor for predicting future health and metabolic disease. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2022
• August 2022

Our results imply a role for IgG-mediated inflammation in determining delayed-type hypersensitivity associated with asymptomatic leishmaniasis ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2017
• January 2017

this study is the first to show an association between immune activation history in the mother and increased ASD symptom severity in children with ASD ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2018
• August 2018

The dramatic rise in allergic disease has occurred in tandem with recent environmental changes and increasing indoor lifestyle culture. While multifactorial, one consistent allergy risk factor has been reduced sunlight exposure. However, vitamin D supplementation studies have been disappointing in preventing allergy, raising possible independent effects of ultraviolet (UV) light exposure. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2021
• May 2021

T cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematologic malignancy with inferior outcome compared with that of B cell ALL. Here, we show that Runt-related transcription factor 2 (RUNX2) was upregulated in high-risk T-ALL with KMT2A rearrangements (KMT2A-R) or an immature immunophenotype. In KMT2A-R cells, we identified RUNX2 as a direct target of the KMT2A chimeras, where it reciprocally bound the KMT2A promoter, establishing a regulatory feed-forward mechanism. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2021
• March 2021

We discovered a previously unknown major resistance mechanism in glioma in that most EGFR domain III-targeting antibodies do not neutralize EGFRvIII ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2019
• April 2019

The association between parental smoking and risk of childhood acute lymphoblastic leukemia (ALL) was investigated in an Australian population-based... ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2011
• December 2011

Recent birth cohort studies showed a significant interaction between cat ownership at birth and mutations in FLG on the development of early‐onset atopic dermatitis ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2020
• June 2020

Monique Robinson MR PhD MPsych (Clin) MAPS NHMRC Early Career Fellow 08 6319 1406 monique.robinson@telethonkids.org.au NHMRC Early Career Fellow she/her/hers Dr Monique Robinson completed PhD and MPsych (Clinical) degrees at The University of ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2011
• January 2011

This paper examines whether adolescents can be reliably categorized into subgroups based on their patterns of anxiety levels over time and whether low levels of social support from parents, peers, and their school, and high levels of peer victimization, predict a pattern of increasing anxiety. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2022
• January 2022