Ependymomas (EPN) are the third most common malignant brain cancer in children. Treatment strategies for pediatric EPN have remained unchanged over recent decades, with 10-year survival rates stagnating at just 67% for children aged 0-14 years. Moreover, a proportion of patients who survive treatment often suffer long-term neurological side effects as a result of therapy. It is evident that there is a need for safer, more effective treatments for pediatric EPN patients. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2023
• March 2023

This study provides evidence to support annual inactivated influenza vaccine administration to children following allogeneic haematopoietic stem cell transplant ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2020
• April 2020

Viridans group streptococci (VGS) are an important cause of sepsis in immunosuppressed children. We reviewed the effectiveness of risk-stratified addition of vancomycin to empiric febrile neutropenia therapy among 107 children with leukemia or undergoing an allogeneic transplant. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2021
• September 2021

We identified consistent hypomethylation of the CTGF locus in primary pre-B ALL specimens regardless of CTGF expression. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2013
• August 2013

The bone marrow microenvironment plays a key role in leukemia progression, but its molecular complexity in pre-B cell acute lymphoblastic leukemia (B-ALL), the most common cancer in children, remains poorly understood. To gain further insight, we used single-cell RNA sequencing to characterize the kinetics of the murine BMM during B-ALL progression. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2021
• November 2021

The trivalent inactivated influenza vaccine is safe, immunogenic, provides clinical protection and should be administered annually to immunosuppressed children receiving treatment for cancer ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2016
• February 2016

Sébastien Rishi Sury Laurence Timo Malinge Kotecha Cheung Lassmann SM RS LC T PhD MB ChB (Hons) MRCPCH FRACP PhD BPharm (Hons) MBA PhD BSc (Hons) MSc PhD Laboratory Head, Translational Genomics in Leukaemia, Ursula Kees Fellow (CCRF), Cancer ...

• 1. Telethon Kids Institute
• Projects

Acute lymphoblastic leukemia and childhood brain tumors are 2 of the most common forms of childhood cancer, but little is known of their etiology. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2015
• January 2015

Invasive fungal infections are more common in children with high-risk acute lymphoblastic leukaemia and in relapsed disease ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2019
• October 2019

Malignant mesothelioma (MM) of the pleura or peritoneum is a universally fatal disease attracting an increasing range of medical interventions and escalating... ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2011
• July 2011

Terrance W. Joost Ben Johns Lesterhuis Wylie T WJL BW BSc PhD Honorary Research Associate Program Head, Cancer; Chronic and Severe Diseases RFA Deputy Head Research Fellow, Sarcoma Translation Research Joost.Lesterhuis@telethonkids.org.au ben.wylie@ ...

• 1. Telethon Kids Institute
• Projects

The functional effects of increased ERBB4 activation identify ERBB4 as a potential prognostic and therapeutic target ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2018
• July 2018