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        Plasma Adenosine Deaminase (ADA)-1 and -2 Demonstrate Robust Ontogeny Across the First Four Months of Human Life

        Human adenosine deaminases (ADAs) modulate the immune response: ADA1 via metabolizing adenosine, a purine metabolite that inhibits pro-inflammatory and Th1 cytokine production, and the multi-functional ADA2, by enhancing T-cell proliferation and monocyte differentiation. Newborns are relatively deficient in ADA1 resulting in elevated plasma adenosine concentrations and a Th2/anti-inflammatory bias compared to adults. ...

        Research

        Supporting Parents as their Child’s First Teacher: Aboriginal Parents’ Perceptions of KindiLink

        This paper reports on Aboriginal parents’ perceptions about their involvement in a Western Australian pilot initiative called KindiLink. The program seeks to support parents as their child’s first teacher and thereby enhance Aboriginal children’s early-years development, while strengthening relationships between families and schools. A constructivist paradigm was used to inform the methodology which placed Aboriginal voices at the centre of the research. ...

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        A systematic review of chronobiology for neonatal care units: What we know and what we should consider

        A Cochrane 2016 review indicated cycled light might benefit neonatal health in hospital. We systematically reviewed chronobiological factors for neonatal health in hospital units, identifying 56 relevant studies on light-dark cycles, feeding, noise, massage therapy, rooming-in, incubators vs. cribs, neonatal units vs. homes, and time-of-day of birth. Empirical evidence for benefits from chronobiology is weaker than expected, including light. ...

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        Age invariance in rapid facial affective reactions to emotionally valenced stimuli

        Rapid facial reactions to emotional stimuli are intact in late adulthood, even in response to stimuli that activate more automatic and implicit forms of emotion processing ...

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        Improving self-regulation and executive functioning skills in primary school children in a remote Australian Aboriginal community: A pilot study of the Alert Program®

        This community partnered pilot research, evaluated a school-based program to reduce the behavioral impact of fetal alcohol spectrum disorder ...

        Research

        Worries, 'weirdos', neighborhoods and knowing people: a qualitative study with children and parents regarding children's independent mobility

        This study involved focus groups with 132 children and 12 parents in primary and secondary school in Victoria to explore children's independent mobility. ...

        Research

        Associations between negative life experiences and the mental health of trans and gender diverse young people in Australia: Findings from Trans Pathways

        The current results highlight the urgent need for better mental health care and provide insight into areas for targeted mental health interventions ...

        Research

        Exposure to Ultraviolet Radiation in the Modulation of Human Diseases

        This review focuses primarily on the beneficial effects for human health of exposure to ultraviolet radiation ...

        Research

        Still keen and committed: piloting an instrument for identifying positive veteran teachers

        Initial findings suggest the potential of the instrument in helping identifying positive veteran teachers within systems, as well as the voracity of the research approach ...

        Research

        A CHAF1B-Dependent Molecular Switch in Hematopoiesis and Leukemia Pathogenesis

        Here we report that CHAF1B is required for normal hematopoiesis while its overexpression promotes leukemia ...

        Research

        Human Primary Epithelial Cell Models: Promising Tools in the Era of Cystic Fibrosis Personalized Medicine

        In this Review, we consolidate the latest updates in the development of primary epithelial cellular model systems relevant for cystic fibrosis ...

        Research

        Multiancestry association study identifies new asthma risk loci that colocalize with immune-cell enhancer marks

        We identified new asthma loci, found new associations at loci implicated in the comorbidity of asthma plus hay fever and confirmed nine known loci. ...

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