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        Effect of human rhinovirus infection on airway epithelium tight junction protein disassembly and transepithelial permeability

        HRV-1B infection directly alters human airway epithelial TJ expression leading to increased epithelial permeability potentially via antiviral response of IL-15 ...

        Research

        Global, regional, and national disability-adjusted life-years (DALYs) for 315 diseases and injuries and healthy life expectancy (HALE), 1990–2015

        Total global disability-adjusted life-years remained largely unchanged from 1990 to 2015 ...

        Research

        A Phase 3 Randomized, Double-blind, Placebo-controlled Study to Evaluate the Safety and Efficacy of MEDI8897, a Monoclonal Antibody With an Extended Half-life Against Respiratory Syncytial Virus, in Healthy Late Preterm and Term Infants (MELODY)

        Jennifer Peter Kent Richmond J PC RN MBBS MRCP(UK) FRACP Clinical Research Manager Head, Vaccine Trials Group Jennifer.Kent@telethonkids.org.au Clinical Research Manager Head, Vaccine Trials Group Jennifer completed her Diploma of Nursing in 1986 at ...

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        Roadmap to incorporating group A Streptococcus molecular point-of-care testing for remote Australia: a key activity to eliminate rheumatic heart disease

        Jonathan Asha Dylan Rosemary Janessa Carapetis AM Bowen Barth Wyber Pickering JR AC DB R Dr AM MBBS FRACP FAFPHM PhD FAHMS BA MBBS DCH FRACP PhD GAICD OAM B.Tech, MPH, PhD MBChB MPH FRACGP PhD BSc PhD Executive Director; Head, Strep A Translation; ...

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        PATZ1 fusions define a novel molecularly distinct neuroepithelial tumor entity with a broad histological spectrum

        Large-scale molecular profiling studies in recent years have shown that central nervous system (CNS) tumors display a much greater heterogeneity in terms of molecularly distinct entities, cellular origins and genetic drivers than anticipated from histological assessment. ...

        Research

        Conduct of neuro-oncology multidisciplinary team meetings and closing the "gaps" in the clinical management of childhood central nervous system tumors in a middle-income country

        Multidisciplinary team meetings (MDTMs) are essential in the clinical management of pediatric central nervous system (CNS) tumors. Evaluations of the impact of MDTMs on childhood CNS tumors and clinicians' perspectives on their effectiveness are scarce. ...

        Research

        Meningococcal serotype W septic arthritis: Case series in children

        The epidemiology of invasive meningococcal disease has changed over the last decade and there has been an increase in cases caused by serogroup W135, particularly in Indigenous children. Extra‐meningeal and atypical presentations are associated with serogroup W and may delay diagnosis and therefore appropriate treatment. Public and clinician awareness are essential in facilitating effective new vaccine schedule implementation. ...

        Research

        Severe and Complicated Varicella and Associated Genotypes 10 Years After Introduction of a One-Dose Varicella Vaccine Program

        Severe hospitalized varicella still occurs with a 1-dose varicella program, although predominantly in unvaccinated children ...

        Research

        Preparing for Life: Plasma Proteome Changes and Immune System Development During the First Week of Human Life

        Neonates have heightened susceptibility to infections. The biological mechanisms are incompletely understood but thought to be related to age-specific adaptations in immunity due to resource constraints during immune system development and growth. We present here an extended analysis of our proteomics study of peripheral blood-plasma from a study of healthy full-term newborns delivered vaginally, collected at the day of birth and on day of life (DOL) 1, 3, or 7, to cover the first week of life. The plasma proteome was characterized by LC-MS using our established 96-well plate format plasma proteomics platform. ...

        Research

        Immunogenicity and Safety of a Quadrivalent Meningococcal ACWY-tetanus Toxoid Conjugate Vaccine 6 Years After MenC Priming as Toddlers

        One dose of MenACWY-TT boosts protection against MenC in primed children, is safe and extends protection against MenA, MenW and MenY ...

        Research

        Lot-to-lot consistency of a tetravalent dengue vaccine in healthy adults in Australia: A randomised study

        This trial tested the safety & consistency of the immune responses elicited by three consecutive lots of tetravalent dengue vaccine. ...

        Research

        Five-Year Antibody Persistence And Safety Following a Combined Haemophilus Influenzae Neisseria Meningitidis Tetanus Toxoid Vaccines

        The purpose of this article is to investigate whether the number and timing of stressors experienced during pregnancy impacted longterm motor development at... ...

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