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        Higher Serum Immunoglobulin G3 Levels May Predict the Development of Multiple Sclerosis in Individuals With Clinically Isolated Syndrome

        IgG3 levels and proportions of IgG3 (%IgG) in serum at CIS diagnosis were inversely correlated with the time until conversion to MS ...

        Research

        Tryptophan and arginine catabolic enzymes and regulatory cytokines in clinically isolated syndrome and multiple sclerosis

        Higher IDO and ARG expression in clinically isolated syndrome and multiple sclerosis provides one sustained homeostatic mechanism to control multiple sclerosis-associated inflammation ...

        Research

        Comprehensive investigation of congenital anomalies in cerebral palsy: Protocol for a European-Australian population-based data linkage study

        The aim of this study is to generate new knowledge about the aetiologies of CP through a focused investigation into the role of congenital anomalies ...

        Research

        Structure-function relationships of the neisserial EptA enzyme responsible for phosphoethanolamine decoration of lipid A: Rationale for drug targeting

        This review concentrates on the phosphoethanolamine decoration of lipid A in the pathogenic species of the genus Neisseria ...

        Research

        Airway Interleukin-33 and type 2 cytokines in adult patients with acute asthma

        Airway interleukin-33 is associated with type-2 cytokines in naturally occurring asthma exacerbations in adults ...

        Research

        Very Early Identification and Intervention for Infants at Risk of Neurodevelopmental Disorders: A Transdiagnostic Approach

        In this article, we examine the utility of a transdiagnostic, dimensional approach to very early identification and intervention for infants at risk of neurodevelopmental disorders ...

        Research

        The impact of respiratory viruses on lung health after preterm birth

        The aim of this review is to highlight the risk factors that may contribute to increased susceptibility to viral respiratory infections among preterm infants ...

        Research

        PI3K activation in neural stem cells drives tumorigenesis which can be ameliorated by targeting the cAMP response element binding protein

        Our findings present a novel mouse model for glioma demonstrating that the PI3K pathway is important for initiation of tumorigenesis ...

        Research

        Early life innate immune signatures of persistent food allergy

        Early life innate immune dysfunction may represent a key immunological driver and predictor of persistent food allergy in childhood ...

        Research

        Exposure to chorioamnionitis alters the monocyte transcriptional response to the neonatal pathogen Staphylococcus epidermidis

        Our findings suggest that prenatal exposure to inflammation may alter the risk of sepsis in preterm infants partly by modulation of monocyte responses to pathogens ...

        Research

        Renal and Cardiovascular Risk According to Tertiles of Urinary Albumin-to-Creatinine Ratio: The Adolescent Type 1 Diabetes Cardio-Renal Intervention Trial (AdDIT)

        Urinary albumin-to-creatinine ratios at the higher end of the normal range at the age of 10-16 years is associated with an increased risk of progression to microalbuminuria ...

        Research

        ISPAD Clinical Practice Consensus Guidelines 2018: Assessment and management of hypoglycemia in children and adolescents with diabetes

        Hypoglycemia is the commonest acute complication of type 1 diabetes ...

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