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        217-228 of 1816 results for 'early childhood/'

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        Sex dimorphism in the relation between early adiposity and cardiometabolic risk in adolescents

        Birth weight and childhood adiposity are associated with subsequent cardiovascular risk. We investigated the associations between metabolic clusters in young... ...

        Research

        Adiposity associated DNA methylation signatures in adolescents are related to leptin and perinatal factors

        Epigenetics links perinatal influences with later obesity. We identifed differentially methylated CpG (dmCpG) loci measured at 17 years associated with concurrent adiposity measures and examined whether these were associated with hsCRP, adipokines, and early life environmental factors. Genome-wide DNA methylation from 1192 Raine Study participants at 17 years, identified 29 dmCpGs associated with body mass index, 10 with waist circumference and 9 with subcutaneous fat thickness. ...

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        Immunosuppressive mechanisms of oncofetal reprogramming in the tumor microenvironment: implications in immunotherapy response

        Both fetal and tumor tissue microenvironments display immunosuppressive features characterized by the presence of specific immunomodulatory stromal and immune cell populations. Recently, we discovered shared microenvironments between hepatocellular carcinoma and fetal tissues and described this phenomenon as an oncofetal ecosystem. ...

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        Airway Microbiota Dynamics Uncover a Critical Window for Interplay of Pathogenic Bacteria and Allergy in Childhood Respiratory Disease

        To complement early allergic sensitization, monitoring NPM composition may enable early detection and intervention in high-risk children ...

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        Australian Study of Causes of Acute Lymphoblastic Leukaemia in Children

        Liz Carol Ursula Milne Bower Kees E C UR MPH PhD MBBS MSc PhD FAFPHM DLSHTM FPHA PhD Honorary Emeritus Fellow Senior Principal Research Fellow, Alcohol and Pregnancy & FASD Research; Director, FASD Research Australia CRE Honorary Emeritus Fellow 08 ...

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        Machine Learning-Based DNA Methylation Score for Fetal Exposure to Maternal Smoking

        Fetal exposure to maternal smoking during pregnancy is associated with the development of noncommunicable diseases in the offspring. Maternal smoking may induce such long-term effects through persistent changes in the DNA methylome, which therefore hold the potential to be used as a biomarker of this early life exposure. With declining costs for measuring DNA methylation, we aimed to develop a DNA methylation score that can be used on adolescent DNA methylation data and thereby generate a score for in utero cigarette smoke exposure. ...

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        Neonatal bacterial sepsis

        Neonatal sepsis remains one of the key challenges of neonatal medicine, and together with preterm birth, causes almost 50% of all deaths globally for children younger than 5 years. Compared with advances achieved for other serious neonatal and early childhood conditions globally, progress in reducing neonatal sepsis has been much slower, especially in low-resource settings that have the highest burden of neonatal sepsis morbidity and mortality. ...

        Research

        Maternal pre-pregnancy body mass index and internalizing and externalizing problems in offspring

        Exposure to elevated maternal pre-pregnancy BMI is associated with increased levels of internalizing and externalizing problems throughout childhood and... ...

        Research

        Good-quality diet in the early years may have a positive effect on academic achievement

        Quality of early diet may be a predictor for later academic achievement ...

        Research

        The non-specific effects of maternal immunization on birth outcomes: The evidence, mechanisms, and the implications

        Preterm birth (PTB) and stillbirth remain two of the most important causes of death, morbidity, and disability in childhood. Despite efforts to reduce PTB and stillbirth worldwide, rates of these adverse outcomes remain persistently elevated, independent of income setting. There is an urgent need for more effective interventions to reduce associated neonatal and early childhood morbidity and mortality. ...

        Research

        Population Wide Monitoring of Child Health and Development in Tuvalu

        Alanna Sincovich AS BPsych(Hons), PhD Senior Research Officer 08 6375 6108 Alanna.sincovich@telethonkids.org.au Senior Research Officer @AlannaSincovich Alanna is a Senior Research Officer at the Telethon Kids Institute. Her research takes a ...

        Research

        Methodological approach to exploring change in the Australia Early Development Instrument (AEDI): The estimation of a critical difference

        This report provides the technical details for the methodology calculated to determine "how big" a difference in the AEDI results between 2009 and 2012 is... ...

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