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        Detecting genotyping error using measures of degree of Hardy-Weinberg disequilibrium - art. no. 5

        Tests for Hardy-Weinberg equilibrium (HWE) have been used to detect genotyping error, but those tests have low power unless the sample size is very large. ...

        Research

        Risk of childhood acute lymphoblastic leukaemia following parental occupational exposure to pesticides

        Risk of childhood acute lymphoblastic leukaemia following parental occupational exposure to pesticides. ...

        Research

        Respiratory infection- and asthma-prone, low vaccine responder children demonstrate distinct mononuclear cell DNA methylation pathways

        nfants with frequent viral and bacterial respiratory infections exhibit compromised immunity to routine immunizations. They are also more likely to develop chronic respiratory diseases in later childhood. This study investigated the feasibility of epigenetic profiling to reveal endotype-specific molecular pathways with potential for early identification and immuno-modulation.  ...

        Research

        Interaction between filaggrin mutations and neonatal cat exposure in atopic dermatitis

        Recent birth cohort studies showed a significant interaction between cat ownership at birth and mutations in FLG on the development of early‐onset atopic dermatitis ...

        Research

        Maternal BMI at the start of pregnancy and offspring epigenome-wide DNA methylation: Findings from the pregnancy and childhood epigenetics (PACE) consortium

        we meta-analysed the association between pre-pregnancy maternal BMI and methylation at over 450,000 sites in newborn blood DNA, across 19 cohorts. ...

        Research

        Meta-analysis of genome-wide association studies identifies three new risk loci for atopic dermatitis

        Atopic dermatitis (AD) is a commonly occurring chronic skin disease with high heritability. Apart from filaggrin (FLG), the genes influencing atopic... ...

        Research

        Folate pathway gene polymorphisms, maternal folic acid use, and risk of childhood acute lymphoblastic leukaemia

        Several studies suggest that maternal folic acid supplementation before or during pregnancy protects against childhood acute lymphoblastic leukaemia (ALL). ...

        Research

        Association between male genital anomalies and adult male reproductive disorders: a population-based data linkage study spanning more than 40 years

        Undescended testes is associated with an increased risk of testicular cancer and male infertility, and decreased paternity ...

        Research

        Genome-wide association analysis identifies 13 new risk loci for schizophrenia

        Common genetic variation has an important role in the etiology of schizophrenia, and larger studies will allow more detailed understanding of this disorder. ...

        Research

        Anti-Interleukin-10 Unleashes Transcriptional Response to Leishmanial Antigens in Visceral Leishmaniasis Patients

        Visceral leishmaniasis (VL; Leishmania donovani) cases produce interferon-γ and tumor necrosis factor in response to soluble leishmanial antigen in whole-blood assays. Using transcriptional profiling, we demonstrate the impact of interleukin-10, a cytokine implicated in VL, on this response. ...

        Research

        Incidental inequity

        Reporting incidental genomic findings requires various considerations. One of these is that 'the clinical validity and utility of variants should be known'. ...

        Research

        A microbiome case-control study of recurrent acute otitis media identified potentially protective bacterial genera

        We characterised the nasopharyngeal microbiome of these children in comparison to children with rAOM to identify potentially protective bacteria. ...

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