Invasive fungal infections are more common in children with high-risk acute lymphoblastic leukaemia and in relapsed disease ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2019
• October 2019

Malignant mesothelioma (MM) of the pleura or peritoneum is a universally fatal disease attracting an increasing range of medical interventions and escalating... ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2011
• July 2011

Terrance W. Joost Ben Johns Lesterhuis Wylie T WJL BW BSc PhD Honorary Research Associate Program Head, Cancer; Chronic and Severe Diseases RFA Deputy Head Research Fellow, Sarcoma Translation Research Joost.Lesterhuis@telethonkids.org.au ben.wylie@ ...

• 1. Telethon Kids Institute
• Projects

Immune checkpoint therapy (ICT) results in durable responses in individuals with some cancers, but not all patients respond to treatment. ICT improves CD8+ cytotoxic T lymphocyte (CTL) function, but changes in tumor antigen-specific CTLs post-ICT that correlate with successful responses have not been well characterized. Here, we studied murine tumor models with dichotomous responses to ICT. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2020
• November 2020

NUT carcinoma (NC), previously known as NUT midline carcinoma, is a rare and very aggressive cancer that occurs in both children and adults. NC is largely chemoresistant, with an overall survival of less than 7 months. Because the carcinoma is not restricted to a particular organ, diagnosis is often a challenge. In the absence of a clearly determined incidence for NC, we sought to study the diagnosis of patients in a well-defined population. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2021
• June 2021

Haematological malignancies, although a broad range of specific disease types, continue to show considerable overlap in classification, and patients are... ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2015
• May 2015

Nick Raelene Terrance Gottardo Endersby Johns NG R T MBChB FRACP PhD BSc (Hons) PhD Co-Head, Brain Tumour Research Brainchild Fellow; Co-Head, Brain Tumour Research Honorary Research Associate nicholas.gottardo@telethonkids.org.au raelene.endersby@ ...

• 1. Telethon Kids Institute
• Projects

Laurence Rishi Sury Sébastien Cheung Kotecha Malinge LC RS SM BPharm (Hons) MBA PhD MB ChB (Hons) MRCPCH FRACP PhD PhD Co-Head, Leukaemia Translational Research Co-Head, Leukaemia Translational Research Laboratory Head, Translational Genomics in ...

• 1. Telethon Kids Institute
• Projects

Invasive fungal disease (IFD) remains a common and serious complication in children treated for leukaemia. Antifungal prescription in children with leukaemia presents unique challenges, particularly due to variation in IFD risk between and within leukaemia treatment protocols, drug toxicities and interactions between antifungals and chemotherapeutic agents. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2022
• May 2022

Human embryonic stem cell-derived neural stem cells (hESC-NSCs) are an attractive cell type for studying ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2010
• April 2010

This study contributes to our understanding of the genetic diversity of NMC, an important step towards finding therapeutic targets for a disease that is... ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2012
• November 2012

The aim of this analysis was to investigate whether maternal coffee or tea consumption during pregnancy was associated with the risk of CBT. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2014
• July 2014