We aimed to evaluate the effect of undernutrition on sputum culture conversion and treatment outcomes among people with multidrug-resistant tuberculosis. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2023
• January 2023

This natural experiment investigated the influence of early childhood education and care outdoor physical environment upgrade on preschoolers' physical activity ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2020
• January 2020

Conventional vaccine design has been based on trial-and-error approaches, which have been generally successful. However, there have been some major failures in vaccine development and we still do not have highly effective licensed vaccines for tuberculosis, HIV, respiratory syncytial virus, and other major infections of global significance. Approaches at rational vaccine design have been limited by our understanding of the immune response to vaccination at the molecular level. Tools now exist to undertake in-depth analysis using systems biology approaches, but to be fully realized, studies are required in humans with intensive blood and tissue sampling. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2020
• November 2020

The gut microbiome is a well-recognized modulator of host immunity, and its compositions differ between geographically separated human populations. Systemic innate immune responses to microbial derivatives also differ between geographically distinct human populations. However, the potential role of the microbiome in mediating geographically varied immune responses is unexplored. We here applied 16S amplicon sequencing to profile the stool microbiome and, in parallel, measured whole-blood innate immune cytokine responses to several pattern recognition receptor (PRR) agonists among 2-year-old children across biogeographically diverse settings. Microbiomes differed mainly between high- and low-resource environments and were not strongly associated with other demographic factors. We found strong correlations between responses to Toll-like receptor 2 (TLR2) and relative abundances of Bacteroides and Prevotella populations, shared among Canadian and Ecuadorean children. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2021
• January 2021

The role of the anti-Müllerian hormone (AMH) as an indicator of physical and reproductive health in men is unclear. We assessed the relationships between AMH and follicle-stimulating hormone (FSH), luteinizing hormone (LH), testosterone, and metabolic parameters, in a cohort of expectant fathers. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2022
• March 2022

To assess parental awareness of respiratory syncytial virus (RSV) and the level of acceptance of future RSV prevention strategies. A cross-sectional online survey was implemented targeting "future" and "current" parents of children aged ≤5 years in Australia. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2024
• February 2024

Nontypeable Haemophilus influenzae (NTHI) strains are responsible for respiratory-related infections which cause a significant burden of disease in... ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2014
• February 2014

Pregnancy and birth cohorts have been utilised extensively to investigate the developmental origins of health and disease, particularly in relation to... ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2015
• April 2015

This study investigated the potential role of ST2 in children with acute asthma. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2009
• March 2009

This review discusses early brain development and the etiological factors that may give rise to atypical developmental trajectories, along with neuroimaging insights ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2019
• March 2019

Brad Carrington Raewyn Carol Melissa Farrant Shepherd Mutch Michie O'Donnell Photos BM CCJ RM C M BSc (Hons), PhD PhD MBChB., DipRACOG., Cert.HPRT, FRACP., PhD BPsych (Hons), MPsych, GradDip Ed, PhD Co-Head, Aboriginal Health and Wellbeing Honorary ...

• 1. Telethon Kids Institute
• Projects

Skin infection burden in remote Aboriginal communities can be reduced by the See, Treat, Prevent (SToP skin sores and scabies) trial ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2019
• September 2019